Emblica officinalis reduces the initiation of oxidative stress by salmonella typhimurium in mice and can be used in typhoid

 

Autores
Khan, Kishwar H.
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2010
País
Argentina
Institución
Universidad Nacional de La Plata
Repositorio
SEDICI (UNLP)
Descripción
Typhoid fever remains an important cause of illness globally with the annual incidence at 21 million cases, of which many end fatally. Due to increasing resistant to antibiotics and limited available vaccine against salmonella, the requirement is to explore the plant products against this disease. Mice pretreated with lyophilized juice of Emblica oficinalis (EO) orally at a dose of 500 mg/kg (EO500) body weight for 20 and 30 days showed full protection against 1X100000 CFU and 2X100000 CFU of S. typhimurium respectively. Mice pretreated with EO500 for 30 days and then challenged with 50000 CFU of S. typhimurium intraperitonially showed reduced CAT and LPO activity by 6.8% and 98%, respectively and increased GSH activity by 67% as compared to saline infected control. The experimental data indicated that regular intake of EO inhibit the induction of oxidative stress by S. typhimurium in mice and may reduce the risk of getting typhoid fever.
Idioma
inglés
OAI Identifier
oai:sedici.unlp.edu.ar:10915/7891
Enlace del recurso
http://sedici.unlp.edu.ar/handle/10915/7891
http://hdl.handle.net/10915/7891
http://www.latamjpharm.org/resumenes/29/2/LAJOP_29_2_1_2.pdf
Nivel de acceso
Acceso abierto
Materia
Farmacia
Farmacología
Enfermedades infecciosas
Extractos de plantas
catalase; emblica officinalis; GSH; LPO; oxidative stress; typhoid