Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression

 

Autores
Bacigalupo, Maria Lorena; Carabias, Pablo; Troncoso, María Fernanda
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2017
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial for treatment. Galectin-1 (Gal-1) belongs to a family of glycan-binding proteins, or lectins, with the ability to cross-link specific glycoconjugates. A variety of biological activities have been attributed to Gal-1 at different steps of tumor progression. Herein, we summarize the current literature regarding the roles of Gal-1 in gastrointestinal malignancies. Accumulating evidence shows that Gal-1 is drastically up-regulated in human gastric cancer, hepatocellular carcinoma, colorectal cancer and pancreatic ductal adenocarcinoma tissues, both in tumor epithelial and tumor-associated stromal cells. Moreover, Gal-1 makes a crucial contribution to the pathogenesis of gastrointestinal malignancies, favoring tumor development, aggressiveness, metastasis, immunosuppression and angiogenesis. We also highlight that alterations in Gal-1-specific glycoepitopes may be relevant for gastrointestinal cancer progression. Despite the findings obtained so far, further functional studies are still required. Elucidating the precise molecular mechanisms modulated by Gal-1 underlying gastrointestinal tumor progression, might lead to the development of novel Gal-1-based diagnostic methods and/or therapies.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/47198
Enlace del recurso
http://hdl.handle.net/11336/47198
Nivel de acceso
Acceso abierto
Materia
GALECTIN-1
GASTRIC CANCER
HEPATOCELLULAR CARCINOMA
COLORECTAL CARCINOMA
PANCREATIC CANCER
BETA1,6-N-ACETILGLUCOSAMINYLTRANSFERASE V
Inmunología
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD