Immunopathogenesis of reactive arthritis: role of the cytokines

 

Autores
Eliçabe, Ricardo Javier; Di Genaro, Maria Silvia
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2014
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
Reactive arthritis (ReA), also known as postinfectious arthritis, belongs to the group of related arthropathies known as spondyloarthritis (SpA). ReA can arise 1-4 weeks after a gastrointestinal or genitourinary infection, but once arthritis develops the microorganism is not found in the joint. The classical microbes associated with ReA development include Gram-negative aerobic or microaerophilic bacteria containing LPS in their outer membrane. The immunopathogenic mechanisms involved in ReA development are still unknown. A hypothesis suggested that the bacteria probably persist outside the joint, at sites such as gut mucosa or lymph nodes and bacterial antigens might then be transported to the joints. On the other hand, an altered immune response and the unbalanced production of cytokines have been reported in subjects with ReA. Currently, there is increased evidence to suggest that both mechanisms would operate in the immunopathogenesis of ReA. In this review we highlight recent advances on the role of cytokines in the ReA. Particularly, we discuss the roles of some pro- and anti-inflammatory cytokines involved in the immunopathogenesis of ReA.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/14503
Enlace del recurso
http://hdl.handle.net/11336/14503
Nivel de acceso
Acceso abierto
Materia
Reactive arthritis
Cytokines
Immunophatogenesis
Infection
Interleukin-17
Interleukin-12
Interleukin-23
Interleukin-6
Tumor necrosis factor-α
Interleukin-10
Inmunología
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD