Effects of strenuous exercise on baseline ventricular function and inotropic, chronotropic and lusitropic response in mice

 

Autores
Wilensky, Luciana; González, Germán Esteban; D'Anunzio, Verónica; Matorra, Luis Federico; Pérez, Virginia; Gullace, Federico Armando; Cicale, Eliana Magalí; Bárcena Barbeira, Pilar; Morales, Celina; Gelpi, Ricardo Jorge
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2013
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
Background: Mild to moderate exercise reduces cardiovascular risk factors, improves pre-existing pathological conditions and develops adaptive cardiac hypertrophy. However, the myocardial response to strenuous exercise is scarcely known. Objective: The aim of this study was to evaluate baseline ventricular function and myocardial reserve (inotropic, chronotropic and lusitropic response to the β-adrenergic agonist isoproterenol) in vivo and in vitro in mice following strenuous exercise. Methods: Three-month old male FVB mice were used. The protocol exercise consisted in 90 min swimming sessions twice a day, 6 days/week for 4 weeks. Two experimental groups were studied: 1) sedentary group, with no exercise; and 2) exercise group, with full strenuous swimming protocol. Results: At the end of the protocol, left ventricular mass increased by 27.9±4% with preserved baseline left ventricular function. In vivo and in vitro myocardial response to isoproterenol decreased with no changes in interstitial collagen. Conclusions: Under our experimental conditions, a strenuous swimming protocol produced moderate cardiac hypertrophy with adaptive and maladaptive hypertrophic characteristics. Although baseline ventricular function was preserved with no changes in interstitial collagen, inotropic, chronotropic and lusitropic reserve decreased.
Idioma
español
OAI Identifier
oai:ri.conicet.gov.ar:11336/21455
Enlace del recurso
http://hdl.handle.net/11336/21455
Nivel de acceso
Acceso abierto
Materia
Exercise
Hypertrophy
Ventricular Function
Otras Medicina Básica
Medicina Básica
CIENCIAS MÉDICAS Y DE LA SALUD