Potential conservation of circadian clock proteins in the phylum Nematoda as revealed by bioinformatic searches

 

Autores
Romanowski, Andrés; Garavaglia, Matías Javier; Goya, María Eugenia; Ghiringhelli, Pablo Daniel; Golombek, Diego Andres
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2014
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
Although several circadian rhythms have been described in C. elegans, its molecular clock remains elusive. In this work we employed a novel bioinformatic approach, applying probabilistic methodologies, to search for circadian clock proteins of several of the best studied circadian model organisms of different taxa (Mus musculus, Drosophila melanogaster, Neurospora crassa, Arabidopsis thaliana and Synechoccocus elongatus) in the proteomes of C. elegans and other members of the phylum Nematoda. With this approach we found that the Nematoda contain proteins most related to the core and accessory proteins of the insect and mammalian clocks, which provide new insights into the nematode clock and the evolution of the circadian system.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/23135
Enlace del recurso
http://hdl.handle.net/11336/23135
Nivel de acceso
Acceso abierto
Materia
C elegans
Clock-proteins
Evolution
Bioinformatic
Bioquímica y Biología Molecular
Ciencias Biológicas
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