Bone changes caused by experimental <i>Solanum malacoxylon</i> poisoning in rabbits

 

Autores
Aguirre, José Ignacio; Gomar, María Soledad; Igal, Silvio; Quiroga, María Alejandra; Portiansky, Enrique Leo; Gimeno, Eduardo Juan
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2005
País
Argentina
Institución
Universidad Nacional de La Plata
Repositorio
SEDICI (UNLP)
Descripción
The aim of this study was to describe the bone changes observed after a daily oral administration of the calcinogenic plant Solanum malacoxylon (syn. S. glaucophyllum) (Sm) during 9 days. The Sm-poisoned rabbits had an increase of bone resorption in the endosteal surface of the cortical zone and an also in the surface covered by osteoblasts of the primary and secondary spongiosa of the trabecular bone compartment. Moreover, the epiphyseal growth plates in long bones appeared narrower than in the control rabbits, with reduction of the proliferative and hyperthrophic chondrocyte zones. The electron microscopic study revealed a significant decrease of proteoglycans in the hyperthrophic chondrocyte zone evidenced by a significant reduction of rutenium red positive granules in the poisoned rabbit. Altogether, these data suggest that cell differentiation may play a pivotal role in the pathogenesis of Sm-induced bone lesions.
Idioma
inglés
OAI Identifier
oai:sedici.unlp.edu.ar:10915/35631
Enlace del recurso
http://sedici.unlp.edu.ar/handle/10915/35631
http://hdl.handle.net/10915/35631
http://www.scielo.br/pdf/pvb/v25n1/23871.pdf
Nivel de acceso
Acceso abierto
Materia
Ciencias Veterinarias
proteoglycan
ruthenium red
bone growth
carcinogenicity
epiphysis
pathogenesis
trabecular bone
Oryctolagus cuniculus
bone tissue
calcinogenic plant
growth plate
rabbit
S. Glaucophyllum
Solanum malacoxylon