Development and release kinetics of a novel formulation of nimesulide prepared by microencapsulation using synthetic polymers

 

Autores
Ranjha, Nazar M.; Iqbal, Furqan; Madni, Asadullah; Usman, Muhammad; Ahmad, Mahmood; Aamir, Muhammad N.
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2011
País
Argentina
Institución
Universidad Nacional de La Plata
Repositorio
SEDICI (UNLP)
Descripción
The synthetic polymers and their combinations were employed to retard the release of nimesulide from microcapsules. Microcapsules were prepared in different ratios of Eudragit RL 100 and hydroxy propyl methyl cellulose (HPMC) separately and in combination. All formulations of microcapsules were compressed to tablets. Dissolution of microcapsules and their tablets was performed by USP-apparatus-II in 900 mL borate buffer of pH 8.4 at 37.0 ± 0.5 ºC, at 50 rpm. In vitro kinetics was determined by various models including Zero order, First Order, Higuchi, Korsmeyer-Peppas and Hixson-Crowell. Eudragit showed higher retarding effect over extended period of time on release of drug than HPMC alone or its combination with Eudragit.
Idioma
inglés
OAI Identifier
oai:sedici.unlp.edu.ar:10915/8263
Enlace del recurso
http://sedici.unlp.edu.ar/handle/10915/8263
http://hdl.handle.net/10915/8263
http://www.latamjpharm.org/resumenes/30/6/LAJOP_30_6_1_5.pdf
Nivel de acceso
Acceso abierto
Materia
Farmacia
Agentes Antiinflamatorios no Esteroides
Sistemas de Liberación de Medicamentos
eudragit; HPMC; microencapsulation; nimesulide; release kinetics