Antinociceptive activity of acetylbergenin in mice

 

Autores
Borges, Jaqueline C. M.; Ripardo Filho, Haroldo da S.; Guilhon, Giselle M.S.P.; Carvalho, José C. T.; Santos, Lourivaldo S.; Sousa, Pergentino J.C.
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2011
País
Argentina
Institución
Universidad Nacional de La Plata
Repositorio
SEDICI (UNLP)
Descripción
Endopleura uchi (Huber) Cuatrec. (Humiriaceae), a Brazilian Amazon plant, is used in folk medicine for the treatment of arthritis. Bergenin, one of the chemical constituents of E. uchi, has several biological activities, including anti-inflammatory properties. Acetylbergenin was obtained from acetylation of bergenin to investigate the antinociceptive effect assessed in models of nociception in mice. This compound dosed at 1, 5, 10, 15 and 25 mg/kg in the writhing test reduced the abdominal constrictions in a significant manner, in 28.2 %, 52.7 %, 61.1 %, 68.3 % and 95.0 %, respectively with ED50 of 6.8 mg/kg. Acetylbergenin in the hot plate test was assayed at 6.8 mg/kg producing no alterations in the latency time when compared to the control. It was tested at 6.8 mg/kg in the formalin test inhibiting significantly the second phase of the algic stimulous, in 88.3 %. These results suggest that acetylbergenin has analgesic activity, probably of peripheral origin. The mechanism involved is not completely understood, however, the results suggest that the opioid system must be involved in the antinociceptive action.
Idioma
inglés
OAI Identifier
oai:sedici.unlp.edu.ar:10915/8298
Enlace del recurso
http://sedici.unlp.edu.ar/handle/10915/8298
http://hdl.handle.net/10915/8298
http://www.latamjpharm.org/resumenes/30/7/LAJOP_30_7_1_8.pdf
Nivel de acceso
Acceso abierto
Materia
Farmacia
Plantas Medicinales
Analgésicos
Compuestos Fenólicos
acetylbergenin; antinociceptive activity; bergenin; endopleura uchi