The lipid transfer protein StarD7: structure, function, and regulation

 

Autores
Flores Martín, Jésica Belén; Rena, Viviana Celeste del Valle; Angeletti, Sofia Claudia; Panzetta-Dutari, Graciela Maria del Valle; Genti de Raimondi, Susana
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2013
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
The steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain proteins constitute a family of evolutionarily conserved and widely expressed proteins that have been implicated in lipid transport, metabolism, and signaling. The 15 well-characterized mammalian START domain-containing proteins are grouped into six subfamilies. The START domain containing 7 mRNA encodes StarD7, a member of the StarD2/phosphatidylcholine transfer protein (PCTP) subfamily, which was first identified as a gene overexpressed in a choriocarcinoma cell line. Recent studies show that the StarD7 protein facilitates the delivery of phosphatidylcholine to the mitochondria. This review summarizes the latest advances in StarD7 research, focusing on the structural and biochemical features, protein-lipid interactions, and mechanisms that regulate StarD7 expression. The implications of the role of StarD7 in cell proliferation, migration, and differentiation are also discussed.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/10954
Enlace del recurso
http://hdl.handle.net/11336/10954
Nivel de acceso
Acceso abierto
Materia
StarD7
START domain
SF-1
β-catenin
ABCG2
Cell migration
Cell proliferation
Bioquímica y Biología Molecular
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS