The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats

 

Autores
Larsen, Karen Elizabeth; Lifschitz, Adrian Luis; Lanusse, Carlos Edmundo; Virkel, Guillermo Leon
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2016
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues. The AChE activity in brain was higher (p < 0.05) than those observed in kidney (females: 2.2-fold; males: 1.9-fold), liver (females: 6-fold; males: 6.9-fold) and plasma (females: 14.7-fold; males: 25.3-fold). Enzyme activities were higher in presence of 10 mM GLP compared to those measured at an equimolar concentration of the potent AChE inhibitor dichlorvos (DDVP). Moreover, IC50s for GLP resulted between 6 × 104- and 6.8 × 105-fold higher than those observed for DDVP. In conclusion, GLP is a weak inhibitor of AChE in rats.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/58481
Enlace del recurso
http://hdl.handle.net/11336/58481
Nivel de acceso
Acceso abierto
Materia
ACETYLCHOLINESTERASE
DICHLORVOS
GLYPHOSATE
RATS
Salud Ocupacional
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD