BtpB, a novel Brucella TIR-containing effector protein with immune modulatory functions.

 

Autores
Salcedo, Suzana P.; Marchesini, Maria Ines; Degos, Clara; Terwagne, Matthiew; Von Bargen, Kristine; Lepidi, Hubert; Herrmann, Claudia Karina; Santos Lacerda, Thais L.; Imbert, Paul R. C.; Pierre, Philippe; Alexopoulou, Lena; Letesson, Jean Jacques; Comerci, Diego José; Gorvel, Jean Pierre
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2013
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
Several bacterial pathogens have TIR domain-containing proteins that contribute to their pathogenesis. We identified a second TIR-containing protein in Brucella spp. that we have designated BtpB. We show it is a potent inhibitor of TLR signaling, probably via MyD88. BtpB is a novel Brucella effector that is translocated into host cells and interferes with activation of dendritic cells. In vivo mouse studies revealed that BtpB is contributing to virulence and control of local inflammatory responses with relevance in the establishment of chronic brucellosis. Together, our results show that BtpB is a novel Brucella effector that plays a major role in the modulation of host innate immune response during infection.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/24837
Enlace del recurso
http://hdl.handle.net/11336/24837
Nivel de acceso
Acceso abierto
Materia
BRUCELLA
TIR DOMAIN
TLR
DENDRITIC CELLS
Btp1/BtpA
DC
NF-κB
Bioquímica y Biología Molecular
Ciencias Biológicas
CIENCIAS NATURALES Y EXACTAS