Autophagy: Eating Myself as a Requirement for the Skin Health

 

Autores
Rinflerch, Adriana Raquel; De Luca, David Aldo; Miretti, Marcos Mateo; Galimberti, Ricardo Luis
Tipo de recurso
artículo
Estado
Versión publicada
Año de publicación
2017
País
Argentina
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio
CONICET Digital (CONICET)
Descripción
Cells recycle their components during starvation through aprocess called autophagy. It is a normal cellular mechanism related tophysiological actions such as nutrient and energy metabolism.In the skin as in other organs, one normal function of autophagyis related to the immune system as the control of mycotic, bacterialand viral infections. Genetic alterations cause amino acid substitutionsin proteins, when it?s involved to autophagy compounds, results inalterations of the defense mechanisms of the host. They have beenrecently involved in the pathogenesis of immunological disorderssuch as systemic lupus erythematosus, vitiligo and oral lichen planus.Furthermore, alterations in autophagy process induce a moreaggressive behavior and reduced life expectancy in squamouscell carcinoma and malignant melanoma. The aim of this review isdescribe the molecular process of autophagy and how alterations ofcomponents of this process are linked to the development of diversesskin pathologies.The understanding of molecular mechanisms involved inautophagy promises new diagnostic and treatment perspectives,mainly in autoimmune diseases and skin cancer.
Idioma
inglés
OAI Identifier
oai:ri.conicet.gov.ar:11336/46434
Enlace del recurso
http://hdl.handle.net/11336/46434
Nivel de acceso
Acceso abierto
Materia
AUTOPHAGY
AUTOIMMUNE
SKIN
VITILIGO
Salud Ocupacional
Ciencias de la Salud
CIENCIAS MÉDICAS Y DE LA SALUD