Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue

Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our s...

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Autores: Mac Keon, Soledad, Gazzaniga, Silvina Noemí, Mallerman, Julieta, Bravo, Alicia Inés, Mordoh, Jose, Wainstok, Rosa
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2010
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/14719
Acceso en línea:http://hdl.handle.net/11336/14719
Access Level:acceso abierto
Palabra clave:Vaccination
Melanoma
Dendritic Cell
Apoptotic Cell
Lymphoid Tissue
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
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spelling Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue Mac Keon, Soledad Gazzaniga, Silvina Noemí Mallerman, Julieta Bravo, Alicia Inés Mordoh, Jose Wainstok, Rosa Vaccination Melanoma Dendritic Cell Apoptotic Cell Lymphoid Tissue https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our system and to find out if there is an immunological response taking place at the vaccination site. The formation of a pseudocapsule, peripheral node addresin expression in small venules, and the recruitment of a wide variety of cellular populations, including macrophages, polymorphonuclear lymphocytes, and CD8+ and CD4+ T lymphocytes found in association with DC, evidenced the formation of tertiary lymphoid tissue in the vaccination site in our experimental system. Fil: Mac Keon, Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Gazzaniga, Silvina Noemí. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Mallerman, Julieta. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina Fil: Bravo, Alicia Inés. Provincia de Buenos Aires. Ministerio de Salud. Hospital Interzonal de Agudos "Eva Peron"; Argentina Fil: Mordoh, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina. Fundación Instituto Leloir; Argentina Fil: Wainstok, Rosa. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica; Argentina. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquimicas de Buenos Aires; Argentina Elsevier http://hdl.handle.net/11336/14719 Mac Keon, Soledad; Gazzaniga, Silvina Noemí; Mallerman, Julieta; Bravo, Alicia Inés; Mordoh, Jose; et al.; Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue; Elsevier; Vaccine; 28; 51; 11-2010; 8162-8168 1873-2518
title Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
spellingShingle Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
Mac Keon, Soledad
Vaccination
Melanoma
Dendritic Cell
Apoptotic Cell
Lymphoid Tissue
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
title_full Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
title_fullStr Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
title_full_unstemmed Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
title_sort Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue
author Mac Keon, Soledad
author_facet Mac Keon, Soledad
Gazzaniga, Silvina Noemí
Mallerman, Julieta
Bravo, Alicia Inés
Mordoh, Jose
Wainstok, Rosa
author_role author
author2 Gazzaniga, Silvina Noemí
Mallerman, Julieta
Bravo, Alicia Inés
Mordoh, Jose
Wainstok, Rosa
author2_role author
author
author
author
author
topic Vaccination
Melanoma
Dendritic Cell
Apoptotic Cell
Lymphoid Tissue
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic_facet Vaccination
Melanoma
Dendritic Cell
Apoptotic Cell
Lymphoid Tissue
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Antigen presentation by dendritic cells (DC) is of key importance for the initiation of the primary immune response. Mice vaccinated with DC charged with apoptotic/necrotic B16 cells (DC-Apo/Nec) are protected against B16 challenge. The aim of this study was to assess vaccine cell migration in our system and to find out if there is an immunological response taking place at the vaccination site. The formation of a pseudocapsule, peripheral node addresin expression in small venules, and the recruitment of a wide variety of cellular populations, including macrophages, polymorphonuclear lymphocytes, and CD8+ and CD4+ T lymphocytes found in association with DC, evidenced the formation of tertiary lymphoid tissue in the vaccination site in our experimental system.
publishDate 2010
format article
status_str publishedVersion
url http://hdl.handle.net/11336/14719
identifier_str_mv Mac Keon, Soledad; Gazzaniga, Silvina Noemí; Mallerman, Julieta; Bravo, Alicia Inés; Mordoh, Jose; et al.; Vaccination with dendritic cells charged with apoptotic/necrotic B16 melanoma induces the formation of subcutaneous lymphoid tissue; Elsevier; Vaccine; 28; 51; 11-2010; 8162-8168
1873-2518
language eng
eu_rights_str_mv openAccess
publisher Elsevier
institution Consejo Nacional de Investigaciones Científicas y Técnicas
collection CONICET Digital (CONICET)
reponame_str CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
_version_ 1878402843455520768
publishDateSort 2010
author_browse Bravo, Alicia Inés
Gazzaniga, Silvina Noemí
Mac Keon, Soledad
Mallerman, Julieta
Mordoh, Jose
Wainstok, Rosa
publisherStr Elsevier
score 6,924472

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