Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients
The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), or...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/57507 |
| Acceso en línea: | http://hdl.handle.net/11336/57507 |
| Access Level: | acceso abierto |
| Palabra clave: | ARGENTINE ORAL CANCER ORAL POTENTIALLY MALIGNANT DISORDERS P53 CODON 72 POLYMORPHISM https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
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oai:ri.conicet.gov.ar:11336/57507 |
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Argentina |
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Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients Zarate, Ana Maria Don, Julieta Secchi, Dante Gustavo Carrica, Victoriano Andrés Galíndez Costa, María Fernanda Panico, René Luis Brusa, Martin Eduardo Barra, Jose Luis Brunotto, Mabel Noemí ARGENTINE ORAL CANCER ORAL POTENTIALLY MALIGNANT DISORDERS P53 CODON 72 POLYMORPHISM https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in argentine patients. Fil: Zarate, Ana Maria. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Don, Julieta. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Secchi, Dante Gustavo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Carrica, Victoriano Andrés. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Galíndez Costa, María Fernanda. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Panico, René Luis. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Brusa, Martin Eduardo. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Fil: Barra, Jose Luis. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Brunotto, Mabel Noemí. Universidad Nacional de Cordoba. Facultad de Odontologia. Departamento de Biologia Bucal; Argentina Karger http://hdl.handle.net/11336/57507 Zarate, Ana Maria; Don, Julieta; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Galíndez Costa, María Fernanda; et al.; Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients; Karger; Tumor Biology; 39; 5; 5-2017 1010-4283 1423-0380 CONICET Digital CONICET |
| title |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients |
| spellingShingle |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients Zarate, Ana Maria ARGENTINE ORAL CANCER ORAL POTENTIALLY MALIGNANT DISORDERS P53 CODON 72 POLYMORPHISM https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| title_short |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients |
| title_full |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients |
| title_fullStr |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients |
| title_full_unstemmed |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients |
| title_sort |
Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients |
| author |
Zarate, Ana Maria |
| author_facet |
Zarate, Ana Maria Don, Julieta Secchi, Dante Gustavo Carrica, Victoriano Andrés Galíndez Costa, María Fernanda Panico, René Luis Brusa, Martin Eduardo Barra, Jose Luis Brunotto, Mabel Noemí |
| author_role |
author |
| author2 |
Don, Julieta Secchi, Dante Gustavo Carrica, Victoriano Andrés Galíndez Costa, María Fernanda Panico, René Luis Brusa, Martin Eduardo Barra, Jose Luis Brunotto, Mabel Noemí |
| author2_role |
author author author author author author author author |
| topic |
ARGENTINE ORAL CANCER ORAL POTENTIALLY MALIGNANT DISORDERS P53 CODON 72 POLYMORPHISM https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| topic_facet |
ARGENTINE ORAL CANCER ORAL POTENTIALLY MALIGNANT DISORDERS P53 CODON 72 POLYMORPHISM https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| description |
The aim of this work was to evaluate the prevalence of TP53Arg72Pro mutations and their possible relationship with oral carcinoma and oral potentially malignant disorders in Argentine patients. A cross-sectional study was performed on 111 exfoliated cytologies from patients with oral cancer (OC), oral potentially malignant disorders (OPMD) and controls. The TP53Arg72Pro mutations were determined using conventional PCR. We evaluated univariate and multivariate study variables, setting p < 0.05. We found: (a) a low frequency of Pro72 variant in control group and a high frequency in OC and OPMD, as well in OC and oral leukoplakia (OL) diagnosis; (b) multivariate association among the TP53CC genotype and females over 45 years with no tobacco nor alcohol habits with oral lichen planus pathology; (c) multivariate association between the TP53GC genotype and males with alcohol and tobacco habits and OC and OL pathologies. Our results showed that the wild-type Arg72variant was related to control patients and Pro72variant was related to OC and OPMD, in argentine patients. |
| publishDate |
2017 |
| format |
article |
| status_str |
publishedVersion |
| url |
http://hdl.handle.net/11336/57507 |
| identifier_str_mv |
Zarate, Ana Maria; Don, Julieta; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Galíndez Costa, María Fernanda; et al.; Study of the TP53 codon 72 polymorphism in oral cancer and oral potentially malignant disorders in argentine patients; Karger; Tumor Biology; 39; 5; 5-2017 1010-4283 1423-0380 CONICET Digital CONICET |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| publisher |
Karger |
| institution |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| collection |
CONICET Digital (CONICET) |
| reponame_str |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| _version_ |
1878402982572195840 |
| publishDateSort |
2017 |
| author_browse |
Barra, Jose Luis Brunotto, Mabel Noemí Brusa, Martin Eduardo Carrica, Victoriano Andrés Don, Julieta Galíndez Costa, María Fernanda Panico, René Luis Secchi, Dante Gustavo Zarate, Ana Maria |
| publisherStr |
Karger |
| score |
6,9460754 |