PED in 2021: A major update of the protein ensemble database for intrinsically disordered proteins

The Protein Ensemble Database (PED) (https://proteinensemble.org), which holds structural ensembles of intrinsically disordered proteins (IDPs), has been significantly updated and upgraded since its last release in 2016. The new version, PED 4.0, has been completely redesigned and reimplemented with...

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Detalles Bibliográficos
Autores: Lazar, Tamas, Martinez Perez, Elizabeth, Quaglia, Federica, Hatos, András, Chemes, Lucia Beatriz, Iserte, Javier Alonso, Méndez, Nicolás Agustín, Garrone, Nicolás Agustín, Saldaño, Tadeo Enrique, Marchetti, Julia, Velez Rueda, Ana Julia, Bernadó, Pau, Blackledge, Martin, Cordeiro, Tiago N., Fagerberg, Eric, Forman Kay, Julie D, Fornasari, Maria Silvina, Gibson, Toby James, Gomes, Gregory Neal W, Gradinaru, Claudiu C., Head Gordon, Teresa, Jensen, Malene Ringkjøbing, Lemke, Edward A, Longhi, Sonia, Marino Buslje, Cristina, Minervini, Giovanni, Mittag, Tanja, Monzon, Alexander Miguel, Pappu, Rohit V., Parisi, Gustavo Daniel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/164928
Acceso en línea:http://hdl.handle.net/11336/164928
Access Level:acceso abierto
Palabra clave:ENSEMBLE
DISORDER
PROTEINS
IDP
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
Descripción
Sumario:The Protein Ensemble Database (PED) (https://proteinensemble.org), which holds structural ensembles of intrinsically disordered proteins (IDPs), has been significantly updated and upgraded since its last release in 2016. The new version, PED 4.0, has been completely redesigned and reimplemented with cutting-edge technology and now holds about six times more data (162 versus 24 entries and 242 versus 60 structural ensembles) and a broader representation of state of the art ensemble generation methods than the previous version. The database has a completely renewed graphical interface with an interactive feature viewer for region-based annotations, and provides a series of descriptors of the qualitative and quantitative properties of the ensembles. High quality of the data is guaranteed by a new submission process, which combines both automatic and manual evaluation steps. A team of biocurators integrate structured metadata describing the ensemble generation methodology, experimental constraints and conditions. A new search engine allows the user to build advanced queries and search all entry fields including cross-references to IDP-related resources such as DisProt, MobiDB, BMRB and SASBDB. We expect that the renewed PED will be useful for researchers interested in the atomic-level understanding of IDP function, and promote the rational, structure-based design of IDP-targeting drugs.

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