A change of view: Homologous recombination at single-molecule resolution

Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture...

Descripción completa

Detalles Bibliográficos
Autores: Kaniecki, Kyle, de Tullio, Luisina, Greene, Eric C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Institución:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/95815
Acceso en línea:http://hdl.handle.net/11336/95815
Access Level:acceso abierto
Palabra clave:SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
id AR_2cb271f4e0a9a3439cc5889aa4fafedb
oai_identifier_str oai:ri.conicet.gov.ar:11336/95815
network_acronym_str AR
network_name_str Argentina
spelling A change of view: Homologous recombination at single-molecule resolution Kaniecki, Kyle de Tullio, Luisina Greene, Eric C. SINGLE MOLECULE HOMOLOGOUS RECOMBINATION FLUORESCENCE MICROSCOPY https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture using ensemble biochemical and genetic approaches is hampered by population heterogeneity and transient recombination intermediates. Recent advances in single-molecule and super-resolution microscopy methods help to overcome these limitations and have led to new and refined insights into recombination mechanisms, including a detailed understanding of DNA helicase function and synaptonemal complex structure. The ability to view cellular processes at single-molecule resolution promises to transform our understanding of recombination and related processes. Fil: Kaniecki, Kyle. Columbia University; Estados Unidos Fil: de Tullio, Luisina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Greene, Eric C.. Columbia University; Estados Unidos Nature Publishing Group http://hdl.handle.net/11336/95815 Kaniecki, Kyle; de Tullio, Luisina; Greene, Eric C.; A change of view: Homologous recombination at single-molecule resolution; Nature Publishing Group; Nature Reviews Genetics; 19; 4; 4-2018; 191-207 1471-0056 CONICET Digital CONICET
title A change of view: Homologous recombination at single-molecule resolution
spellingShingle A change of view: Homologous recombination at single-molecule resolution
Kaniecki, Kyle
SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
title_short A change of view: Homologous recombination at single-molecule resolution
title_full A change of view: Homologous recombination at single-molecule resolution
title_fullStr A change of view: Homologous recombination at single-molecule resolution
title_full_unstemmed A change of view: Homologous recombination at single-molecule resolution
title_sort A change of view: Homologous recombination at single-molecule resolution
author Kaniecki, Kyle
author_facet Kaniecki, Kyle
de Tullio, Luisina
Greene, Eric C.
author_role author
author2 de Tullio, Luisina
Greene, Eric C.
author2_role author
author
topic SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
topic_facet SINGLE MOLECULE
HOMOLOGOUS RECOMBINATION
FLUORESCENCE MICROSCOPY
https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
description Genetic recombination occurs in all organisms and is vital for genome stability. Indeed, in humans, aberrant recombination can lead to diseases such as cancer. Our understanding of homologous recombination is built upon more than a century of scientific inquiry, but achieving a more complete picture using ensemble biochemical and genetic approaches is hampered by population heterogeneity and transient recombination intermediates. Recent advances in single-molecule and super-resolution microscopy methods help to overcome these limitations and have led to new and refined insights into recombination mechanisms, including a detailed understanding of DNA helicase function and synaptonemal complex structure. The ability to view cellular processes at single-molecule resolution promises to transform our understanding of recombination and related processes.
publishDate 2018
format article
status_str publishedVersion
url http://hdl.handle.net/11336/95815
identifier_str_mv Kaniecki, Kyle; de Tullio, Luisina; Greene, Eric C.; A change of view: Homologous recombination at single-molecule resolution; Nature Publishing Group; Nature Reviews Genetics; 19; 4; 4-2018; 191-207
1471-0056
CONICET Digital
CONICET
language eng
eu_rights_str_mv openAccess
publisher Nature Publishing Group
institution Consejo Nacional de Investigaciones Científicas y Técnicas
collection CONICET Digital (CONICET)
reponame_str CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
_version_ 1878403010818736128
publishDateSort 2018
author_browse Greene, Eric C.
Kaniecki, Kyle
de Tullio, Luisina
publisherStr Nature Publishing Group
score 6,9303427

Similares en LA Referencia