Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis
The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the...
| Autores: | , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2005 |
| País: | Argentina |
| Institución: | Consejo Nacional de Investigaciones Científicas y Técnicas |
| Repositorio: | CONICET Digital (CONICET) |
| Idioma: | inglés |
| OAI Identifier: | oai:ri.conicet.gov.ar:11336/39392 |
| Acceso en línea: | http://hdl.handle.net/11336/39392 |
| Access Level: | acceso abierto |
| Palabra clave: | Autoimmune Response Nitric Oxide Signalling Nod Mice Sialadenitis SjÖGren'S Syndrome https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
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Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis Rosignoli, F. Roca, Valeria Ines Meiss, R. Leceta, J. Gomariz, Roberto Luis Perez Leiros, Claudia Autoimmune Response Nitric Oxide Signalling Nod Mice Sialadenitis SjÖGren'S Syndrome https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response. Fil: Rosignoli, F.. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Complutense de Madrid; España Fil: Roca, Valeria Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Meiss, R.. Academia Nacional de Medicina de Buenos Aires; Argentina Fil: Leceta, J.. Universidad Complutense de Madrid; España Fil: Gomariz, R.P.. Universidad Complutense de Madrid; España Fil: Perez Leiros, Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Wiley Blackwell Publishing, Inc http://hdl.handle.net/11336/39392 Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-418 0009-9104 1365-2249 CONICET Digital CONICET |
| title |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis |
| spellingShingle |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis Rosignoli, F. Autoimmune Response Nitric Oxide Signalling Nod Mice Sialadenitis SjÖGren'S Syndrome https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| title_short |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis |
| title_full |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis |
| title_fullStr |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis |
| title_full_unstemmed |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis |
| title_sort |
Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis |
| author |
Rosignoli, F. |
| author_facet |
Rosignoli, F. Roca, Valeria Ines Meiss, R. Leceta, J. Gomariz, Roberto Luis Perez Leiros, Claudia |
| author_role |
author |
| author2 |
Roca, Valeria Ines Meiss, R. Leceta, J. Gomariz, Roberto Luis Perez Leiros, Claudia |
| author2_role |
author author author author author |
| topic |
Autoimmune Response Nitric Oxide Signalling Nod Mice Sialadenitis SjÖGren'S Syndrome https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| topic_facet |
Autoimmune Response Nitric Oxide Signalling Nod Mice Sialadenitis SjÖGren'S Syndrome https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
| description |
The spontaneous non-obese diabetic (NOD) mouse model of Sjögren's syndrome provides a valuable tool to study the onset and progression of both the autoimmune response and secretory dysfunction. Our purpose was to analyse the temporal decline of salivary secretion in NOD mice in relation to the autoimmune response and alterations in various signalling pathways involved in saliva secretion within each salivary gland. A progressive loss of nitric oxide synthase activity in submandibular and parotid glands started at 12 weeks of age and paralleled the decline in salivary secretion. This defect was associated with a lower response to vasoactive intestinal peptide in salivary flow rate, cAMP and nitric oxide/cGMP production. No signs of mononuclear infiltrates or local cytokine production were detectable in salivary glands in the time period studied (10-16 weeks of age). Our data support a disease model for sialadenitis in NOD mice in which the early stages are characterized by defective neurotransmitter-mediated signalling in major salivary glands that precedes the autoimmune response. |
| publishDate |
2005 |
| format |
article |
| status_str |
publishedVersion |
| url |
http://hdl.handle.net/11336/39392 |
| identifier_str_mv |
Rosignoli, F.; Roca, Valeria Ines; Meiss, R.; Leceta, J.; Gomariz, Roberto Luis; et al.; Defective signalling in salivary glands precedes the autoimmune response in the non-obese diabetic mouse model of sialadenitis; Wiley Blackwell Publishing, Inc; Clinical and Experimental Immunology; 142; 3; 12-2005; 411-418 0009-9104 1365-2249 CONICET Digital CONICET |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| publisher |
Wiley Blackwell Publishing, Inc |
| institution |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| collection |
CONICET Digital (CONICET) |
| reponame_str |
CONICET Digital (CONICET) |
| instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
| _version_ |
1878403385406783488 |
| publishDateSort |
2005 |
| author_browse |
Gomariz, Roberto Luis Leceta, J. Meiss, R. Perez Leiros, Claudia Roca, Valeria Ines Rosignoli, F. |
| publisherStr |
Wiley Blackwell Publishing, Inc |
| score |
6,924472 |