Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation

Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fu...

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Autores: Ambrosi, Nella Gabriela, Guerrieri, Diego, Caro, Fiorella Yanina, Sánchez, Francisco, Haeublein, Geraldine Elena, Casadei, Domingo, Incardona, Claudio, Chuluyan, Hector Eduardo
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:Argentina
Recursos:Consejo Nacional de Investigaciones Científicas y Técnicas
Repositorio:CONICET Digital (CONICET)
Idioma:inglés
OAI Identifier:oai:ri.conicet.gov.ar:11336/89749
Acesso em linha:http://hdl.handle.net/11336/89749
Access Level:acceso abierto
Palavra-chave:IRI
ROS
TRANSPLANTATION
Α-LIPOIC ACID
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
id AR_eecdff9ab3eba67b4c0ad9ad0ed0aeab
oai_identifier_str oai:ri.conicet.gov.ar:11336/89749
network_acronym_str AR
network_name_str Argentina
spelling Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation Ambrosi, Nella Gabriela Guerrieri, Diego Caro, Fiorella Yanina Sánchez, Francisco Haeublein, Geraldine Elena Casadei, Domingo Incardona, Claudio Chuluyan, Hector Eduardo IRI ROS TRANSPLANTATION Α-LIPOIC ACID https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fundamental influence on the short and long term organ function. The reactive oxygen species (ROS) produced during the IRI actively participates in these adverse events. Therapeutic strategies that tend to limit the action of free radicals could result in beneficial effects in transplantation outcome. Accordingly, the anti-oxidant α-lipoic acid (ALA) have been proved to be protective in several animal experimental models and humans. In a clinical trial, ALA was found to decrease hepatic IRI after hepatic occlusion and resection. Furthermore, the treatment of cadaveric donor and recipient with ALA had a protective effect in the short-term outcome in simultaneous kidney and pancreas transplanted patients. These studies support ALA as a drug to mitigate the damage caused by IRI and reinforce the knowledge about the deleterious consequences of ROS on graft injury in transplantation. The goal of this review is to overview the current knowledge about ROS in transplantation and the use of ALA to mitigate it. Fil: Ambrosi, Nella Gabriela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Guerrieri, Diego. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Caro, Fiorella Yanina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Sánchez, Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Haeublein, Geraldine Elena. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Fil: Casadei, Domingo. Instituto de Nefrología de Buenos Aires; Argentina Fil: Incardona, Claudio. Instituto Universitario del Hospital Italiano de Buenos Aires; Argentina Fil: Chuluyan, Hector Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina Molecular Diversity Preservation International http://hdl.handle.net/11336/89749 Ambrosi, Nella Gabriela; Guerrieri, Diego; Caro, Fiorella Yanina; Sánchez, Francisco; Haeublein, Geraldine Elena; et al.; Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 19; 1; 4-1-2018; 102 1422-0067 CONICET Digital CONICET
title Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
spellingShingle Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
Ambrosi, Nella Gabriela
IRI
ROS
TRANSPLANTATION
Α-LIPOIC ACID
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
title_short Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
title_full Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
title_fullStr Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
title_full_unstemmed Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
title_sort Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation
author Ambrosi, Nella Gabriela
author_facet Ambrosi, Nella Gabriela
Guerrieri, Diego
Caro, Fiorella Yanina
Sánchez, Francisco
Haeublein, Geraldine Elena
Casadei, Domingo
Incardona, Claudio
Chuluyan, Hector Eduardo
author_role author
author2 Guerrieri, Diego
Caro, Fiorella Yanina
Sánchez, Francisco
Haeublein, Geraldine Elena
Casadei, Domingo
Incardona, Claudio
Chuluyan, Hector Eduardo
author2_role author
author
author
author
author
author
author
topic IRI
ROS
TRANSPLANTATION
Α-LIPOIC ACID
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
topic_facet IRI
ROS
TRANSPLANTATION
Α-LIPOIC ACID
https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
description Organ replacement is an option to mitigate irreversible organ damage. This procedure has achieved a considerable degree of acceptance. However, several factors significantly limit its effectiveness. Among them, the initial inflammatory graft reaction due to ischemia-reperfusion injury (IRI) has a fundamental influence on the short and long term organ function. The reactive oxygen species (ROS) produced during the IRI actively participates in these adverse events. Therapeutic strategies that tend to limit the action of free radicals could result in beneficial effects in transplantation outcome. Accordingly, the anti-oxidant α-lipoic acid (ALA) have been proved to be protective in several animal experimental models and humans. In a clinical trial, ALA was found to decrease hepatic IRI after hepatic occlusion and resection. Furthermore, the treatment of cadaveric donor and recipient with ALA had a protective effect in the short-term outcome in simultaneous kidney and pancreas transplanted patients. These studies support ALA as a drug to mitigate the damage caused by IRI and reinforce the knowledge about the deleterious consequences of ROS on graft injury in transplantation. The goal of this review is to overview the current knowledge about ROS in transplantation and the use of ALA to mitigate it.
publishDate 2018
format article
status_str publishedVersion
url http://hdl.handle.net/11336/89749
identifier_str_mv Ambrosi, Nella Gabriela; Guerrieri, Diego; Caro, Fiorella Yanina; Sánchez, Francisco; Haeublein, Geraldine Elena; et al.; Alpha lipoic acid: A therapeutic strategy that tend to limit the action of free radicals in transplantation; Molecular Diversity Preservation International; International Journal of Molecular Sciences; 19; 1; 4-1-2018; 102
1422-0067
CONICET Digital
CONICET
language eng
eu_rights_str_mv openAccess
publisher Molecular Diversity Preservation International
institution Consejo Nacional de Investigaciones Científicas y Técnicas
collection CONICET Digital (CONICET)
reponame_str CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
_version_ 1878404033851424769
publishDateSort 2018
author_browse Ambrosi, Nella Gabriela
Caro, Fiorella Yanina
Casadei, Domingo
Chuluyan, Hector Eduardo
Guerrieri, Diego
Haeublein, Geraldine Elena
Incardona, Claudio
Sánchez, Francisco
publisherStr Molecular Diversity Preservation International
score 6,9303427

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