Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018
Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil
| Autores: | , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2018 |
| País: | Brasil |
| Institución: | Fundação Oswaldo Cruz (FIOCRUZ) |
| Repositorio: | Repositório Institucional da FIOCRUZ (ARCA) |
| Idioma: | inglés |
| OAI Identifier: | oai:arca.fiocruz.br:icict/27733 |
| Acceso en línea: | https://arca.fiocruz.br/handle/icict/27733 |
| Access Level: | acceso abierto |
| Palabra clave: | febre amarela Yellow fever |
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BR_2cb82cdf720482f2dce1922eb3efa3da |
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oai:arca.fiocruz.br:icict/27733 |
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BR |
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Brasil |
| title |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 |
| spellingShingle |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 Rezende, Izabela Maurício de febre amarela Yellow fever |
| title_short |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 |
| title_full |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 |
| title_fullStr |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 |
| title_full_unstemmed |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 |
| title_sort |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 |
| author |
Rezende, Izabela Maurício de |
| author_facet |
Rezende, Izabela Maurício de Sacchetto, Lívia Mello, Erica Munhoz de Alves, Pedro Augusto Iani, Felipe Campos de Melo Adelino, Talita Émile Ribeiro Duarte, Myrian Morato Cury, Ana Luısa Furtado Bernardes, Andre Felipe Leal Santos, Tayrine Araujo Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Ramalho, Dario Brock Thoisy, Benoit de Kroon, Erna Geessien Trindade, Giliane de Souza Drumond, Betânia Paiva |
| author_role |
author |
| author2 |
Sacchetto, Lívia Mello, Erica Munhoz de Alves, Pedro Augusto Iani, Felipe Campos de Melo Adelino, Talita Émile Ribeiro Duarte, Myrian Morato Cury, Ana Luısa Furtado Bernardes, Andre Felipe Leal Santos, Tayrine Araujo Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Ramalho, Dario Brock Thoisy, Benoit de Kroon, Erna Geessien Trindade, Giliane de Souza Drumond, Betânia Paiva |
| author2_role |
author author author author author author author author author author author author author author author author |
| topic |
febre amarela Yellow fever |
| topic_facet |
febre amarela Yellow fever |
| description |
Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil |
| publishDate |
2018 |
| format |
article |
| status_str |
publishedVersion |
| url |
https://arca.fiocruz.br/handle/icict/27733 |
| identifier_str_mv |
10.1371/journal.pntd.0006538 |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| publisher |
Public Library of Science |
| institution |
FIOCRUZ |
| collection |
Repositório Institucional da FIOCRUZ (ARCA) |
| reponame_str |
Repositório Institucional da FIOCRUZ (ARCA) |
| instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
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https://arca.fiocruz.br/bitstreams/b6ccd7e3-f940-4f28-b06a-e3af51fe647b/download https://arca.fiocruz.br/bitstreams/97a7f353-15f3-46ff-905e-7db296ac25e2/download https://arca.fiocruz.br/bitstreams/1c317b7e-f766-4739-b023-0069ee99c4c7/download https://arca.fiocruz.br/bitstreams/0fadad1f-8c4d-49f3-b1b2-2cd09c489e35/download |
| spelling |
Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018 Rezende, Izabela Maurício de Sacchetto, Lívia Mello, Erica Munhoz de Alves, Pedro Augusto Iani, Felipe Campos de Melo Adelino, Talita Émile Ribeiro Duarte, Myrian Morato Cury, Ana Luısa Furtado Bernardes, Andre Felipe Leal Santos, Tayrine Araujo Pereira, Leonardo Soares Dutra, Maria Rita Teixeira Ramalho, Dario Brock Thoisy, Benoit de Kroon, Erna Geessien Trindade, Giliane de Souza Drumond, Betânia Paiva febre amarela Yellow fever Universidade Federal de Minas Gerais. Departamento de Microbiologia. Laboratorio de Vırus. Belo Horizonte, MG, Brazil Prefeitura de Belo Horizonte. Centro de Controle de Zoonoses. Belo Horizonte, MG, Brazil Fundaçao Oswaldo Cruz. Instituto Rene Rachou. Laboratorio de Imunologia de Doenças Virais. Belo Horizonte, MG, Brazil Fundaçao Ezequiel Dias. Serviço de Virologia e Riquetsioses. Belo Horizonte, MG, Brazil Fundaçao Hospitalar do Estado de Minas Gerais. Hospital Eduardo de Menezes. Belo Horizonte, MG, Brazil Laboratoire des Interaction Virus-Hotes. Institut Pasteur, Cayenne. French Guiana Background: Yellow fever (YF) is endemic in the Brazilian Amazon Basin, and sporadic outbreaks take place outside the endemic area in Brazil. Since 2016, YF epidemics have been occurring in Southeast Brazil, with more than 1,900 human cases and more than 1,600 epizooties of non-human primates (NHPs) reported until April 2018. Previous studies have demonstrated that Yellow fever virus (YFV) causing outbreaks in 2017 formed a monophyletic group. Methodology/Principal findings: Aiming to decipher the origin of the YFV responsible for the recent epidemics, we obtained nucleotide sequences of YFV detected in humans (n = 6) and NHPs (n = 10) from Minas Gerais state during 2017±2018. Next, we performed evolutionary analyses and discussed the results in the light of epidemiological records (official numbers of YFV cases at each Brazilian Federative unit, reported by the Brazilian Ministry of Health). Nucleotide sequences of YFV from Southeast Brazil from 2016 to 2018 were highly conserved and formed a monophyletic lineage (BR-YFV_2016/18) within the genotype South America I. Different clusters were observed within lineage BR-YFV_2016/18, one containing the majority of isolates (from humans and NHPs), indicating the sylvatic transmission of YFV. We also detected a cluster characterized by two synapomorphies (amino acid substitutions) that contained YFV only associated with NHP what should be further investigated. The topology of lineage BRYFV_2016/18 was congruent with epidemiological and temporal patterns of the on going epidemic. YFV isolates detected in 2016, in São Paulo state were located in the most basal position of the lineage, followed by the isolates from Minas Gerais and Espirito Santo obtained in 2017 and 2018. The most recent common ancestor of the lineage BRYFV_2016/18 dated to 2015 (95% credible intervals = 2014±2016), in a period that was coincident with the reemergence of YFV in the Midwest region of Brazil. Conclusions: The results demonstrated a single introduction of YFV in the Southeast region and the silent viral circulation before the onset of the outbreaks in 2016. Evolutionary analyses combined with epidemiological records supported the idea that BR-YFV_2016/18 was probably introduced from the Midwest into the Southeast region, possibly in São Paulo state. The persistence of YFV in the Southeast region, causing epidemics from 2016 to 2018, suggests that this region presents suitable ecological and climatic conditions for YFV maintenance during the epidemic and interepidemic seasons. This fact poses risks for the establishing of YF enzootic cycles and epidemics, outside the Amazon Basin in Brazil. YF surveillance and studies of viral dynamics deserve particular attention, especially in Midwest, Southeast and neighbor regions which are the main areas historically associated with YF outbreaks outside the Amazon Basin. YFV persistence in Southeast Brazil should be carefully considered in the context of public health, especially for public health decision-makers and researchers. Public Library of Science REZENDE, Izabela Maurıcio de et al. Persistence of Yellow fever virus outside the Amazon Basin, causing epidemics in Southeast Brazil, from2016 to 2018. PLoS Negl Trop Dis., v. 12, n. 6, e0006538, 2018 1935-2727 https://arca.fiocruz.br/handle/icict/27733 10.1371/journal.pntd.0006538 |
| _version_ |
1878416415825854464 |
| publishDateSort |
2018 |
| author_browse |
Adelino, Talita Émile Ribeiro Alves, Pedro Augusto Bernardes, Andre Felipe Leal Cury, Ana Luısa Furtado Drumond, Betânia Paiva Duarte, Myrian Morato Dutra, Maria Rita Teixeira Iani, Felipe Campos de Melo Kroon, Erna Geessien Mello, Erica Munhoz de Pereira, Leonardo Soares Ramalho, Dario Brock Rezende, Izabela Maurício de Sacchetto, Lívia Santos, Tayrine Araujo Thoisy, Benoit de Trindade, Giliane de Souza |
| publisherStr |
Public Library of Science |
| score |
6,9008884 |