Human papillomavirus infection in Brazilian women with normal cervical cytology.

We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and pr...

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Bibliographic Details
Authors: Miranda, Priscila Mayrink de, Pitol, Bruna Caroline Vieira, Moran, Mariana Soares, Silva, Nayara Nascimento Toledo, Felix, Priscilla Muller, Lima Filho, José Luiz de, Carneiro, Cláudia Martins, Silva, Ismael Dale Cotrim Guerreiro da, Carvalho, Rodrigo Franco de, Lima, Angélica Alves, Beçak, Willy, Stocco, Rita de Cássia
Format: article
Status:Published version
Publication Date:2012
Country:Brasil
Institution:Universidade Federal de Ouro Preto (UFOP)
Repository:Repositório Institucional da UFOP
Language:English
OAI Identifier:oai:repositorio.ufop.br:123456789/4030
Online Access:http://www.repositorio.ufop.br/handle/123456789/4030
http://dx.doi.org/10.1590/S1517-83822008000300031
Access Level:Open access
Keyword:Human papillomavirus
Cervical cancer screening
Normal cytology
Epidemiology
Risk factors
Description
Summary:We examined the prevalence of human papillomavirus (HPV) infection in a sample of Brazilian women presenting normal cervical cytology. Possible interactions between patient characteristics and HPV infection were analyzed in order to provide background data to improve cervical cancer screening and prophylaxis. Cervical samples of 399 women, received for routine evaluation in the Health Department of Ouro Preto, MG, Brazil, were subjected to HPV-DNA testing by PCR with MY09/11 primers. HPV-positive specimens were typed by RFLP. A structured epidemiological questionnaire was administered to each woman. HPV prevalence among these cytologically normal women was 11%. Twelve viral types were detected, the most common being HPV-16, -6, -61, -83, and -66. HPV was more prevalent in younger women; high-risk viral types were detected in 61% of the infected women and 27% of the infected women had multiple HPV infections. Significant associations of HPV infection were found with age, literacy, residence, marital status, lifetime number of sexual partners, and parity. We detected a great diversity of HPV types in women with normal cytology. This kind of information about local populations is useful for HPV prevention and vaccination strategies.

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