Morphological Investigation of Protective Effects of CDP-Choline on Liver and Small Intestine in an Experimental Sepsis Model in Rats
SUMMARY: Fifty male Wistar albino rats were divided into 5 groups; Group 1 as a sham group. Group 2 as a control group, Group 3 as 100 mg/kg CDP-choline administered group, Group as 200 mg/kg CDP-choline administered group, and Group 5 as sepsis group. The sepsis model was performed by ligating and...
| Authors: | , , , , , , |
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| Format: | article |
| Status: | Published version |
| Publication Date: | 2022 |
| Country: | Chile |
| Institution: | CONICYT Chile |
| Repository: | SciELO Chile |
| OAI Identifier: | oai:scielo:S0717-95022022000601466 |
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022022000601466 |
| Access Level: | Open access |
| Keyword: | CDP-choline Liver Small intestine Tissue damage |
| Summary: | SUMMARY: Fifty male Wistar albino rats were divided into 5 groups; Group 1 as a sham group. Group 2 as a control group, Group 3 as 100 mg/kg CDP-choline administered group, Group as 200 mg/kg CDP-choline administered group, and Group 5 as sepsis group. The sepsis model was performed by ligating and perforating the caecum of rats. Liver and small intestine tissues were assessed either histologically or quantitatively and qualitatively. There was a significant difference between the sepsis and CDP-choline groups for liver and intestinal damage evaluated in tissue samples. (p <0.001). CDP-choline treatment partially improved dose-dependent the clinical parameters of sepsis and septic shock, reversed micro-anatomical damage caused by sepsis. |
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