Toll-like Receptors are Key Participants in Innate Immune Responses
During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. Th...
| Autores: | , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2007 |
| País: | Chile |
| Recursos: | CONICYT Chile |
| Repositorio: | SciELO Chile |
| OAI Identifier: | oai:scielo:S0716-97602007000200001 |
| Acesso em linha: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001 |
| Access Level: | acceso abierto |
| Palavra-chave: | Toll-like receptors Innate Immunity cytokines MyD88 NFkB |
| id |
CL_f1ac36bdea035b7bcb2e68f4c64cc725 |
|---|---|
| oai_identifier_str |
oai:scielo:S0716-97602007000200001 |
| network_acronym_str |
CL |
| network_name_str |
Chile |
| spelling |
Toll-like Receptors are Key Participants in Innate Immune Responses ARANCIBIA,SERGIO A BELTRÁN,CAROLL J AGUIRRE,ISABEL M SILVA,PAULINA PERALTA,ALEXIS L MALINARICH,FRANO HERMOSO,MARCELA A Toll-like receptors Innate Immunity cytokines MyD88 NFkB During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article Sociedad de Biología de Chile http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001 |
| title |
Toll-like Receptors are Key Participants in Innate Immune Responses |
| spellingShingle |
Toll-like Receptors are Key Participants in Innate Immune Responses ARANCIBIA,SERGIO A Toll-like receptors Innate Immunity cytokines MyD88 NFkB |
| title_short |
Toll-like Receptors are Key Participants in Innate Immune Responses |
| title_full |
Toll-like Receptors are Key Participants in Innate Immune Responses |
| title_fullStr |
Toll-like Receptors are Key Participants in Innate Immune Responses |
| title_full_unstemmed |
Toll-like Receptors are Key Participants in Innate Immune Responses |
| title_sort |
Toll-like Receptors are Key Participants in Innate Immune Responses |
| author |
ARANCIBIA,SERGIO A |
| author_facet |
ARANCIBIA,SERGIO A BELTRÁN,CAROLL J AGUIRRE,ISABEL M SILVA,PAULINA PERALTA,ALEXIS L MALINARICH,FRANO HERMOSO,MARCELA A |
| author_role |
author |
| author2 |
BELTRÁN,CAROLL J AGUIRRE,ISABEL M SILVA,PAULINA PERALTA,ALEXIS L MALINARICH,FRANO HERMOSO,MARCELA A |
| author2_role |
author author author author author author |
| topic |
Toll-like receptors Innate Immunity cytokines MyD88 NFkB |
| topic_facet |
Toll-like receptors Innate Immunity cytokines MyD88 NFkB |
| description |
During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article |
| publishDate |
2007 |
| format |
article |
| status_str |
publishedVersion |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001 |
| eu_rights_str_mv |
openAccess |
| publisher |
Sociedad de Biología de Chile |
| institution |
CONICYT |
| collection |
SciELO Chile |
| reponame_str |
SciELO Chile |
| instname_str |
CONICYT Chile |
| _version_ |
1878404808385232898 |
| publishDateSort |
2007 |
| author_browse |
AGUIRRE,ISABEL M ARANCIBIA,SERGIO A BELTRÁN,CAROLL J HERMOSO,MARCELA A MALINARICH,FRANO PERALTA,ALEXIS L SILVA,PAULINA |
| publisherStr |
Sociedad de Biología de Chile |
| score |
6,9303427 |