Neurotoxicity induced by microcystins and cylindrospermopsin: A review

Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense,...

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Autores: Hinojosa Hidalgo, María Gracia, Gutiérrez-Praena, Daniel, Prieto Ortega, Ana Isabel, Guzmán Guillén, Remedios, Jos Gallego, Ángeles Mencía, Cameán Fernández, Ana María
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2019
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/128525
Acceso en línea:https://hdl.handle.net/11441/128525
https://doi.org/10.1016/j.scitotenv.2019.02.426
Access Level:acceso abierto
Palabra clave:Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
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spelling Neurotoxicity induced by microcystins and cylindrospermopsin: A review Hinojosa Hidalgo, María Gracia Gutiérrez-Praena, Daniel Prieto Ortega, Ana Isabel Guzmán Guillén, Remedios Jos Gallego, Ángeles Mencía Cameán Fernández, Ana María Cyanotoxins MCs CYN Nervous system Ecotoxicology Environmental risk Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo, due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases. Ministerio de Economía y Competitividad (AGL2015-64558-R, MINECO/FEDER, UE) Elsevier https://hdl.handle.net/11441/128525 https://doi.org/10.1016/j.scitotenv.2019.02.426
title Neurotoxicity induced by microcystins and cylindrospermopsin: A review
spellingShingle Neurotoxicity induced by microcystins and cylindrospermopsin: A review
Hinojosa Hidalgo, María Gracia
Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
title_short Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_full Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_fullStr Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_full_unstemmed Neurotoxicity induced by microcystins and cylindrospermopsin: A review
title_sort Neurotoxicity induced by microcystins and cylindrospermopsin: A review
author Hinojosa Hidalgo, María Gracia
author_facet Hinojosa Hidalgo, María Gracia
Gutiérrez-Praena, Daniel
Prieto Ortega, Ana Isabel
Guzmán Guillén, Remedios
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author_role author
author2 Gutiérrez-Praena, Daniel
Prieto Ortega, Ana Isabel
Guzmán Guillén, Remedios
Jos Gallego, Ángeles Mencía
Cameán Fernández, Ana María
author2_role author
author
author
author
author
topic Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
topic_facet Cyanotoxins
MCs
CYN
Nervous system
Ecotoxicology
Environmental risk
description Microcystins (MCs) and cylindrospermopsin (CYN) are among the most frequent toxins produced by cyanobacteria. These toxic secondary metabolites are classified as hepatotoxins and cytotoxin, respectively. Furthermore, both may present the ability to induce damage to the nervous system. In this sense, there are many studies manifesting the potential of MCs to cause neurotoxicity both in vitro and in vivo, due to their probable capacity to cross the blood-brain-barrier through organic anion transporting polypeptides. Moreover, the presence of MCs has been detected in brain of several experimental models. Among the neurological effects, histopathological brain changes, deregulation of biochemical parameters in brain (production of oxidative stress and inhibition of protein phosphatases) and behavioral alterations have been described. It is noteworthy that minority variants such as MC-LF and -LW have demonstrated to exert higher neurotoxic effects compared to the most studied congener, MC-LR. By contrast, the available studies concerning CYN-neurotoxic effects are very scarce, mostly showing inflammation and apoptosis in neural murine cell lines, oxidative stress, and alteration of the acetylcholinesterase activity in vivo. However, more studies are required in order to clarify the neurotoxic potential of both toxins, as well as their possible contribution to neurodegenerative diseases.
publishDate 2019
format article
status_str acceptedVersion
url https://hdl.handle.net/11441/128525
https://doi.org/10.1016/j.scitotenv.2019.02.426
eu_rights_str_mv openAccess
publisher Elsevier
institution Universidad de Sevilla (US)
collection idUS. Depósito de Investigación de la Universidad de Sevilla
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
instname_str Universidad de Sevilla (US)
_version_ 1878432611460710401
publishDateSort 2019
author_browse Cameán Fernández, Ana María
Gutiérrez-Praena, Daniel
Guzmán Guillén, Remedios
Hinojosa Hidalgo, María Gracia
Jos Gallego, Ángeles Mencía
Prieto Ortega, Ana Isabel
publisherStr Elsevier
score 6,924472

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