Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?

Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, an...

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Autores: Cordero, Mario D., Díaz-Parrado, Eduardo, Carrión, Ángel Manuel, Alfonsi, Simona, Sánchez Alcázar, José Antonio, Miguel Rodríguez, Manuel de, Battino, Maurizio
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2013
País:España
Institución:Universidad de Sevilla (US)
Repositorio:idUS. Depósito de Investigación de la Universidad de Sevilla
OAI Identifier:oai:idus.us.es:11441/82046
Acceso en línea:https://hdl.handle.net/11441/82046
https://doi.org/10.1089/ars.2012.4892
Access Level:acceso abierto
Palabra clave:Fibromyalgia
mitochondrial dysfunction
inflammation
FM
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spelling Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia? Cordero, Mario D. Díaz-Parrado, Eduardo Carrión, Ángel Manuel Alfonsi, Simona Sánchez Alcázar, José Antonio Miguel Rodríguez, Manuel de Battino, Maurizio Fibromyalgia mitochondrial dysfunction inflammation FM Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r= -0.588; p < 0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; p < 0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms ( p < 0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target. Unión Europea FIS PI10/00543 Servicio Andaluz de Salud Junta de Andalucía SAS 111242 Junta de Andalucía CTS-5725 Mary Ann Liebert, Inc. https://hdl.handle.net/11441/82046 https://doi.org/10.1089/ars.2012.4892
title Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
spellingShingle Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
Cordero, Mario D.
Fibromyalgia
mitochondrial dysfunction
inflammation
FM
title_short Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_full Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_fullStr Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_full_unstemmed Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
title_sort Is Inflammation a Mitochondrial Dysfunction-Dependent Event in Fibromyalgia?
author Cordero, Mario D.
author_facet Cordero, Mario D.
Díaz-Parrado, Eduardo
Carrión, Ángel Manuel
Alfonsi, Simona
Sánchez Alcázar, José Antonio
Miguel Rodríguez, Manuel de
Battino, Maurizio
author_role author
author2 Díaz-Parrado, Eduardo
Carrión, Ángel Manuel
Alfonsi, Simona
Sánchez Alcázar, José Antonio
Miguel Rodríguez, Manuel de
Battino, Maurizio
author2_role author
author
author
author
author
author
topic Fibromyalgia
mitochondrial dysfunction
inflammation
FM
topic_facet Fibromyalgia
mitochondrial dysfunction
inflammation
FM
description Fibromyalgia (FM) is a complex disorder that affects up to 5% of the general population worldwide. Both mitochondrial dysfunction and inflammation have been implicated in the pathophysiology of FM. We have investigated the possible relationship between mitochondrial dysfunction, oxidative stress, and inflammation in FM. We studied 30 women diagnosed with FM and 20 healthy women. Blood mononuclear cells (BMCs) from FM patients showed reduced level of coenzyme Q10 (CoQ10) and mtDNA contents and high level of mitochondrial reactive oxygen species (ROS) and serum tumor necrosis factor (TNF)-alpha and transcript levels. A significant negative correlation between CoQ10 and TNF-alpha levels (r= -0.588; p < 0.01), and a positive correlation between ROS and TNF-alpha levels (r = 0.791; p < 0.001) were observed accompanied by a significant correlation of visual analogical scale with serum TNF-alpha and transcript levels (r = 0.4507; p < 0.05 and r = 0.7089; p < 0.001, respectively). TNF-alpha release was observed in an in vitro (BMCs) and in vivo (mice) CoQ10 deficiency model. Oral CoQ10 supplementation restored biochemical parameters and induced a significant improvement in clinical symptoms ( p < 0.001). These results lead to the hypothesis that inflammation could be a mitochondrial dysfunction-dependent event implicated in the pathophysiology of FM in several patients indicating at mitochondria as a possible new therapeutic target.
publishDate 2013
format article
status_str publishedVersion
url https://hdl.handle.net/11441/82046
https://doi.org/10.1089/ars.2012.4892
eu_rights_str_mv openAccess
publisher Mary Ann Liebert, Inc.
institution Universidad de Sevilla (US)
collection idUS. Depósito de Investigación de la Universidad de Sevilla
reponame_str idUS. Depósito de Investigación de la Universidad de Sevilla
instname_str Universidad de Sevilla (US)
_version_ 1878432838624215042
publishDateSort 2013
author_browse Alfonsi, Simona
Battino, Maurizio
Carrión, Ángel Manuel
Cordero, Mario D.
Díaz-Parrado, Eduardo
Miguel Rodríguez, Manuel de
Sánchez Alcázar, José Antonio
publisherStr Mary Ann Liebert, Inc.
score 6,9303427

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