Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women
Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/101775
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2016 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/103923 |
| Acceso en línea: | https://hdl.handle.net/2445/103923 |
| Access Level: | acceso abierto |
| Palabra clave: | Plasmodium vivax Malària Immunoglobulines Embarassades Malaria Immunoglobulins Pregnant women |
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oai:diposit.ub.edu:2445/103923 |
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Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women Requena, Pilar Rui, Edmilson Padilla, Norma Martínez Espinosa, Flor E. Castellanos, Maria Eugenia Botto Menezes, Camila Malheiro, Adriana Arévalo-Herrera, Myriam Kochar, Swati Kochar, Sanjay K. Kochar, Dhanpat K. Umbers, Alexandra J. Ome-Kaius, Maria Wangnapi, Regina A. Hans, Dhiraj Menegon, Michela Mateo González, Francesca Sanz, Sergi Desai, Meghna Mayor Aparicio, Alfredo Gabriel Chitnis, Chetan E. Bardají, Azucena Mueller, Ivo Rogerson, Stephen John Severini, Carlo Fernández Becerra, María del Carmen Menéndez, Clara Portillo Obando, Hernando A. del Dobaño, Carlota, 1969- Plasmodium vivax Malària Immunoglobulines Embarassades Malaria Immunoglobulins Pregnant women Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/101775 P. vivax infection during pregnancy has been associated with poor outcomes such as anemia, low birth weight and congenital malaria, thus representing an important global health problem. However, no vaccine is currently available for its prevention. Vir genes were the first putative virulent factors associated with P. vivax infections, yet very few studies have examined their potential role as targets of immunity. We investigated the immunogenic properties of five VIR proteins and two long synthetic peptides containing conserved VIR sequences (PvLP1 and PvLP2) in the context of the PregVax cohort study including women from five malaria endemic countries: Brazil, Colombia, Guatemala, India and Papua New Guinea (PNG) at different timepoints during and after pregnancy. Antibody responses against all antigens were detected in all populations, with PNG women presenting the highest levels overall. P. vivax infection at sample collection time was positively associated with antibody levels against PvLP1 (fold-increase: 1.60 at recruitment -first antenatal visit-) and PvLP2 (fold-increase: 1.63 at delivery), and P. falciparum co-infection was found to increase those responses (for PvLP1 at recruitment, fold-increase: 2.25). Levels of IgG against two VIR proteins at delivery were associated with higher birth weight (27 g increase per duplicating antibody levels, p<0.05). Peripheral blood mononuclear cells from PNG uninfected pregnant women had significantly higher antigen-specific IFN-gamma TH1 responses (p=0.006) and secreted less pro-inflammatory cytokines TNF and IL-6 after PvLP2 stimulation than P. vivax-infected women (p<0.05). These data demonstrate that VIR antigens induce the natural acquisition of antibody and T cell memory responses that might be important in immunity to P. vivax during pregnancy in very diverse geographical settings. Public Library of Science (PLoS) https://hdl.handle.net/2445/103923 |
| title |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women |
| spellingShingle |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women Requena, Pilar Plasmodium vivax Malària Immunoglobulines Embarassades Malaria Immunoglobulins Pregnant women |
| title_short |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women |
| title_full |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women |
| title_fullStr |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women |
| title_full_unstemmed |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women |
| title_sort |
Plasmodium vivax VIR Proteins Are Targets of Naturally-Acquired Antibody and T Cell Immune Responses to Malaria in Pregnant Women |
| author |
Requena, Pilar |
| author_facet |
Requena, Pilar Rui, Edmilson Padilla, Norma Martínez Espinosa, Flor E. Castellanos, Maria Eugenia Botto Menezes, Camila Malheiro, Adriana Arévalo-Herrera, Myriam Kochar, Swati Kochar, Sanjay K. Kochar, Dhanpat K. Umbers, Alexandra J. Ome-Kaius, Maria Wangnapi, Regina A. Hans, Dhiraj Menegon, Michela Mateo González, Francesca Sanz, Sergi Desai, Meghna Mayor Aparicio, Alfredo Gabriel Chitnis, Chetan E. Bardají, Azucena Mueller, Ivo Rogerson, Stephen John Severini, Carlo Fernández Becerra, María del Carmen Menéndez, Clara Portillo Obando, Hernando A. del Dobaño, Carlota, 1969- |
| author_role |
author |
| author2 |
Rui, Edmilson Padilla, Norma Martínez Espinosa, Flor E. Castellanos, Maria Eugenia Botto Menezes, Camila Malheiro, Adriana Arévalo-Herrera, Myriam Kochar, Swati Kochar, Sanjay K. Kochar, Dhanpat K. Umbers, Alexandra J. Ome-Kaius, Maria Wangnapi, Regina A. Hans, Dhiraj Menegon, Michela Mateo González, Francesca Sanz, Sergi Desai, Meghna Mayor Aparicio, Alfredo Gabriel Chitnis, Chetan E. Bardají, Azucena Mueller, Ivo Rogerson, Stephen John Severini, Carlo Fernández Becerra, María del Carmen Menéndez, Clara Portillo Obando, Hernando A. del Dobaño, Carlota, 1969- |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| topic |
Plasmodium vivax Malària Immunoglobulines Embarassades Malaria Immunoglobulins Pregnant women |
| topic_facet |
Plasmodium vivax Malària Immunoglobulines Embarassades Malaria Immunoglobulins Pregnant women |
| description |
Podeu consultar dades primàries associades a l'article a: http://hdl.handle.net/2445/101775 |
| publishDate |
2016 |
| format |
article |
| status_str |
publishedVersion |
| url |
https://hdl.handle.net/2445/103923 |
| eu_rights_str_mv |
openAccess |
| publisher |
Public Library of Science (PLoS) |
| institution |
Universidad de Barcelona |
| collection |
Dipòsit Digital de la UB |
| reponame_str |
Dipòsit Digital de la UB |
| instname_str |
Universidad de Barcelona |
| _version_ |
1878432984490573824 |
| publishDateSort |
2016 |
| author_browse |
Arévalo-Herrera, Myriam Bardají, Azucena Botto Menezes, Camila Castellanos, Maria Eugenia Chitnis, Chetan E. Desai, Meghna Dobaño, Carlota, 1969- Fernández Becerra, María del Carmen Hans, Dhiraj Kochar, Dhanpat K. Kochar, Sanjay K. Kochar, Swati Malheiro, Adriana Martínez Espinosa, Flor E. Mateo González, Francesca Mayor Aparicio, Alfredo Gabriel Menegon, Michela Menéndez, Clara Mueller, Ivo Ome-Kaius, Maria Padilla, Norma Portillo Obando, Hernando A. del Requena, Pilar Rogerson, Stephen John Rui, Edmilson Sanz, Sergi Severini, Carlo Umbers, Alexandra J. Wangnapi, Regina A. |
| publisherStr |
Public Library of Science (PLoS) |
| score |
6,9303427 |