Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease

Introduction. Early-onset Alzheimer's disease (EOAD) shows a higher burden of neuropsychiatric symptoms than late-onset Alzheimer's disease (LOAD). We aim to determine the differences in the severity of neuropsychiatric symptoms and locus coeruleus (LC) integrity between EOAD and LOAD acco...

ver descrição completa

Detalhes bibliográficos
Autores: Falgas, Neus, Peña-González, Marta, Guillén, Núria, Morales-Ruiz, Manuel, Sánchez Valle, Raquel
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/71973
Acesso em linha:http://hdl.handle.net/10230/71973
http://dx.doi.org/10.1002/alz.14131
Access Level:acceso abierto
Palavra-chave:Alzheimer's disease
Early-onset Alzheimer's disease
Locus coeruleus
Neuromodulatory subcortical systems
Neuropsychiatric symptoms
Selective vulnerability
id ES_2ed8936dfd6784bef38dc7ddb4852295
oai_identifier_str oai:recercat.cat:10230/71973
network_acronym_str ES
network_name_str España
spelling Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease Falgas, Neus Peña-González, Marta Guillén, Núria Morales-Ruiz, Manuel Sánchez Valle, Raquel Alzheimer's disease Early-onset Alzheimer's disease Locus coeruleus Neuromodulatory subcortical systems Neuropsychiatric symptoms Selective vulnerability Introduction. Early-onset Alzheimer's disease (EOAD) shows a higher burden of neuropsychiatric symptoms than late-onset Alzheimer's disease (LOAD). We aim to determine the differences in the severity of neuropsychiatric symptoms and locus coeruleus (LC) integrity between EOAD and LOAD accounting for disease stage. Methods. One hundred four subjects with AD diagnosis and 32 healthy controls were included. Participants underwent magnetic resonance imaging (MRI) to measure LC integrity, measures of noradrenaline levels in cerebrospinal fluid (CSF) and Neuropsychiatric Inventory (NPI). We analyzed LC-noradrenaline measurements and clinical and Alzheimer's disease (AD) biomarker associations. Results. EOAD showed higher NPI scores, lower LC integrity, and similar levels of CSF noradrenaline compared to LOAD. Notably, EOAD exhibited lower LC integrity independently of disease stage. LC integrity negatively correlated with neuropsychiatric symptoms. Noradrenaline levels were increased in AD correlating with AD biomarkers. Discussion. Decreased LC integrity negatively contributes to neuropsychiatric symptoms. The higher LC degeneration in EOAD compared to LOAD could explain the more severe neuropsychiatric symptoms in EOAD. Highlights. LC degeneration is greater in early-onset AD (EOAD) compared to late-onset AD. Tau-derived LC degeneration drives a higher severity of neuropsychiatric symptoms. EOAD harbors a more profound selective vulnerability of the LC system. LC degeneration is associated with an increase of cerebrospinal fluid noradrenaline levels in AD. Wiley http://hdl.handle.net/10230/71973 http://dx.doi.org/10.1002/alz.14131
title Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
spellingShingle Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
Falgas, Neus
Alzheimer's disease
Early-onset Alzheimer's disease
Locus coeruleus
Neuromodulatory subcortical systems
Neuropsychiatric symptoms
Selective vulnerability
title_short Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
title_full Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
title_fullStr Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
title_full_unstemmed Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
title_sort Locus coeruleus integrity and neuropsychiatric symptoms in a cohort of early- and late-onset Alzheimer's disease
author Falgas, Neus
author_facet Falgas, Neus
Peña-González, Marta
Guillén, Núria
Morales-Ruiz, Manuel
Sánchez Valle, Raquel
author_role author
author2 Peña-González, Marta
Guillén, Núria
Morales-Ruiz, Manuel
Sánchez Valle, Raquel
author2_role author
author
author
author
topic Alzheimer's disease
Early-onset Alzheimer's disease
Locus coeruleus
Neuromodulatory subcortical systems
Neuropsychiatric symptoms
Selective vulnerability
topic_facet Alzheimer's disease
Early-onset Alzheimer's disease
Locus coeruleus
Neuromodulatory subcortical systems
Neuropsychiatric symptoms
Selective vulnerability
description Introduction. Early-onset Alzheimer's disease (EOAD) shows a higher burden of neuropsychiatric symptoms than late-onset Alzheimer's disease (LOAD). We aim to determine the differences in the severity of neuropsychiatric symptoms and locus coeruleus (LC) integrity between EOAD and LOAD accounting for disease stage. Methods. One hundred four subjects with AD diagnosis and 32 healthy controls were included. Participants underwent magnetic resonance imaging (MRI) to measure LC integrity, measures of noradrenaline levels in cerebrospinal fluid (CSF) and Neuropsychiatric Inventory (NPI). We analyzed LC-noradrenaline measurements and clinical and Alzheimer's disease (AD) biomarker associations. Results. EOAD showed higher NPI scores, lower LC integrity, and similar levels of CSF noradrenaline compared to LOAD. Notably, EOAD exhibited lower LC integrity independently of disease stage. LC integrity negatively correlated with neuropsychiatric symptoms. Noradrenaline levels were increased in AD correlating with AD biomarkers. Discussion. Decreased LC integrity negatively contributes to neuropsychiatric symptoms. The higher LC degeneration in EOAD compared to LOAD could explain the more severe neuropsychiatric symptoms in EOAD. Highlights. LC degeneration is greater in early-onset AD (EOAD) compared to late-onset AD. Tau-derived LC degeneration drives a higher severity of neuropsychiatric symptoms. EOAD harbors a more profound selective vulnerability of the LC system. LC degeneration is associated with an increase of cerebrospinal fluid noradrenaline levels in AD.
publishDate 2024
format article
status_str publishedVersion
url http://hdl.handle.net/10230/71973
http://dx.doi.org/10.1002/alz.14131
eu_rights_str_mv openAccess
publisher Wiley
institution Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
collection Recercat. Dipósit de la Recerca de Catalunya
reponame_str Recercat. Dipósit de la Recerca de Catalunya
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
_version_ 1878432985022201856
publishDateSort 2024
author_browse Falgas, Neus
Guillén, Núria
Morales-Ruiz, Manuel
Peña-González, Marta
Sánchez Valle, Raquel
publisherStr Wiley
score 6,924472

Registos relacionados