Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study
Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre...
| Autores: | , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:20.500.12328/1807 |
| Acceso en línea: | http://hdl.handle.net/20.500.12328/1807 https://dx.doi.org/10.3390/jcm9092825 |
| Access Level: | acceso abierto |
| Palabra clave: | Cardiologia Insuficiència cardíaca Qualitat de vida Cardiología Insuficiencia cardíaca Calidad de vida Cardiology Heart failure Life, Quality of 61 616.1 |
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oai:recercat.cat:20.500.12328/1807 |
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España |
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Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study Garay, Alberto Tapia, Javier Anguita, Manuel Formiga, Francesc Almenar, Luis Crespo-Leiro, María G. Manzano, Luis Muñiz, Javier Chaves, José De Frutos, Trinidad Moliner, Pedro Corbella Virós, Xavier Enjuanes-Grau, Cristina Comin-Colet, Josep VIDA-IC Multicenter Study Investigators Cardiologia Insuficiència cardíaca Qualitat de vida Cardiología Insuficiencia cardíaca Calidad de vida Cardiology Heart failure Life, Quality of 61 616.1 Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity. info:eu-repo/semantics/publishedVersion MDPI http://hdl.handle.net/20.500.12328/1807 https://dx.doi.org/10.3390/jcm9092825 |
| title |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study |
| spellingShingle |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study Garay, Alberto Cardiologia Insuficiència cardíaca Qualitat de vida Cardiología Insuficiencia cardíaca Calidad de vida Cardiology Heart failure Life, Quality of 61 616.1 |
| title_short |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study |
| title_full |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study |
| title_fullStr |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study |
| title_full_unstemmed |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study |
| title_sort |
Gender differences in health-related quality of life in patients with systolic heart failure: results of the VIDA multicenter study |
| author |
Garay, Alberto |
| author_facet |
Garay, Alberto Tapia, Javier Anguita, Manuel Formiga, Francesc Almenar, Luis Crespo-Leiro, María G. Manzano, Luis Muñiz, Javier Chaves, José De Frutos, Trinidad Moliner, Pedro Corbella Virós, Xavier Enjuanes-Grau, Cristina Comin-Colet, Josep VIDA-IC Multicenter Study Investigators |
| author_role |
author |
| author2 |
Tapia, Javier Anguita, Manuel Formiga, Francesc Almenar, Luis Crespo-Leiro, María G. Manzano, Luis Muñiz, Javier Chaves, José De Frutos, Trinidad Moliner, Pedro Corbella Virós, Xavier Enjuanes-Grau, Cristina Comin-Colet, Josep VIDA-IC Multicenter Study Investigators |
| author2_role |
author author author author author author author author author author author author author author |
| topic |
Cardiologia Insuficiència cardíaca Qualitat de vida Cardiología Insuficiencia cardíaca Calidad de vida Cardiology Heart failure Life, Quality of 61 616.1 |
| topic_facet |
Cardiologia Insuficiència cardíaca Qualitat de vida Cardiología Insuficiencia cardíaca Calidad de vida Cardiology Heart failure Life, Quality of 61 616.1 |
| description |
Previous studies have shown that heart failure is associated with worse health-related quality of life (HRQoL). The existence of differences according to gender remains controversial. We studied 1028 consecutive outpatients with heart failure and reduced ejection fraction (HFrEF) from a multicentre cross-sectional descriptive study across Spain that assessed HRQoL using two questionnaires (KCCQ, Kansas City Cardiomyopathy Questionnaire; and EQ-5D, EuroQoL 5 dimensions). The primary objective of the study was to describe differences in HRQoL between men and women in global scores and domains of health status of patients and explore gender differences and its interactions with heart failure related factors. In adjusted analysis women had lower scores in KCCQ overall summary scores when compared to men denoting worse HRQoL (54.7 ± 1.3 vs. 62.7 ± 0.8, p < 0.0001), and specifically got lower score in domains of symptom frequency, symptoms burden, physical limitation, quality of life and social limitation. No differences were found in domains of symptom stability and self-efficacy. Women also had lower scores on all items of EQ-5D (EQ-5D index 0.58 ± 0.01 vs. 0.67 ± 0.01, p < 0.0001). Finally, we analyzed interaction between gender and different clinical determinants regarding the presence of limitations in the 5Q-5D and overall summary score of KCCQ. Interestingly, there was no statistical significance for interaction for any variable. In conclusion, women with HFrEF have worse HRQoL compared to men. These differences do not appear to be mediated by clinical or biological factors classically associated with HRQoL nor with heart failure severity. |
| publishDate |
2020 |
| format |
article |
| url |
http://hdl.handle.net/20.500.12328/1807 https://dx.doi.org/10.3390/jcm9092825 |
| eu_rights_str_mv |
openAccess |
| publisher |
MDPI |
| institution |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| _version_ |
1878433651707871232 |
| publishDateSort |
2020 |
| author_browse |
Almenar, Luis Anguita, Manuel Chaves, José Comin-Colet, Josep Corbella Virós, Xavier Crespo-Leiro, María G. De Frutos, Trinidad Enjuanes-Grau, Cristina Formiga, Francesc Garay, Alberto Manzano, Luis Moliner, Pedro Muñiz, Javier Tapia, Javier VIDA-IC Multicenter Study Investigators |
| publisherStr |
MDPI |
| score |
6,924472 |