Oligonucleotide cyclization: The thiol-maleimide reaction revisited
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder condit...
| Autores: | , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2013 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/50383 |
| Acceso en línea: | https://hdl.handle.net/2445/50383 |
| Access Level: | acceso abierto |
| Palabra clave: | Bioquímica Àcids nucleics Bacteris Microbiologia Ciclització (Química) Biochemistry Nucleic acids Bacteria Microbiology Ring formation (Chemistry) |
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ES_4d92dfd26f2b3f084255b7936abe4a95 |
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| oai_identifier_str |
oai:recercat.cat:2445/50383 |
| network_acronym_str |
ES |
| network_name_str |
España |
| spelling |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited Sánchez-Moya, Albert Pedroso Muller, Enrique Grandas Sagarra, Anna Bioquímica Àcids nucleics Bacteris Microbiologia Ciclització (Química) Biochemistry Nucleic acids Bacteria Microbiology Ring formation (Chemistry) A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield. Royal Society of Chemistry https://hdl.handle.net/2445/50383 |
| title |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| spellingShingle |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited Sánchez-Moya, Albert Bioquímica Àcids nucleics Bacteris Microbiologia Ciclització (Química) Biochemistry Nucleic acids Bacteria Microbiology Ring formation (Chemistry) |
| title_short |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| title_full |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| title_fullStr |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| title_full_unstemmed |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| title_sort |
Oligonucleotide cyclization: The thiol-maleimide reaction revisited |
| author |
Sánchez-Moya, Albert |
| author_facet |
Sánchez-Moya, Albert Pedroso Muller, Enrique Grandas Sagarra, Anna |
| author_role |
author |
| author2 |
Pedroso Muller, Enrique Grandas Sagarra, Anna |
| author2_role |
author author |
| topic |
Bioquímica Àcids nucleics Bacteris Microbiologia Ciclització (Química) Biochemistry Nucleic acids Bacteria Microbiology Ring formation (Chemistry) |
| topic_facet |
Bioquímica Àcids nucleics Bacteris Microbiologia Ciclització (Química) Biochemistry Nucleic acids Bacteria Microbiology Ring formation (Chemistry) |
| description |
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield. |
| publishDate |
2013 |
| format |
article |
| status_str |
acceptedVersion |
| url |
https://hdl.handle.net/2445/50383 |
| eu_rights_str_mv |
openAccess |
| publisher |
Royal Society of Chemistry |
| institution |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| _version_ |
1878434408953806849 |
| publishDateSort |
2013 |
| author_browse |
Grandas Sagarra, Anna Pedroso Muller, Enrique Sánchez-Moya, Albert |
| publisherStr |
Royal Society of Chemistry |
| score |
6,9303427 |