The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance
Background: Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help impro...
| Autores: | , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/209205 |
| Acceso en línea: | https://hdl.handle.net/2445/209205 |
| Access Level: | acceso abierto |
| Palabra clave: | Prolactina Psicosi Cognició Oxitocina Diferències entre sexes (Psicologia) Prolactin Psychoses Cognition Oxytocin Sex differences (Psychology) |
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oai:diposit.ub.edu:2445/209205 |
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España |
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The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance Hidalgo Figueroa, María Salazar, Alejandro Romero López-Alberca, Cristina MacDowell, Karina S. García Bueno, Borja Bioque Alcázar, Miquel Bernardo Vilamitjana, Mercè Parellada, Mara González-Pinto, Ana García Portilla, María Paz Lobo, Antonio Rodriguez Jimenez, Roberto Berrocoso, Esther Leza, Juan Carlos Prolactina Psicosi Cognició Oxitocina Diferències entre sexes (Psicologia) Prolactin Psychoses Cognition Oxytocin Sex differences (Psychology) Background: Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help improve the diagnosis, treatment, and outcome of such events and to define new therapeutic targets. Here we analyzed the plasma oxytocin and prolactin levels during an FEP, assessing their correlation with clinical and cognitive features. Methods: The oxytocin and prolactin in plasma was measured in 120 FEP patients and 106 healthy controls, all of whom were subjected to a clinical and neuropsychological assessment. Most patients were under antipsychotics. Statistical analyses aimed to identify factors associated with the FEP and to search for associations between the variables. This study is preliminary and exploratory because the P-values were not corrected for multiple comparisons. Results: FEP patients had less oxytocin, more prolactin, and a poor premorbid IQ, and they performed worse in sustained attention. Male patients with higher prolactin levels experienced more severe psychotic symptoms and required higher doses of antipsychotics. Low oxytocin was associated with poor sustained attention in women, whereas low oxytocin and high prolactin in men correlated with better performance in sustained attention. Conclusion: Low oxytocin, high prolactin, and poor premorbid IQ and sustained attention are factors associated with an FEP, representing potential therapeutic targets in these patients. These biological factors and cognitive domains might play an important role during a FEP, which could help us to develop new strategies that improve the outcomes of this disorder and that should perhaps be gender specific. Oxford University Press https://hdl.handle.net/2445/209205 |
| title |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance |
| spellingShingle |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance Hidalgo Figueroa, María Prolactina Psicosi Cognició Oxitocina Diferències entre sexes (Psicologia) Prolactin Psychoses Cognition Oxytocin Sex differences (Psychology) |
| title_short |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance |
| title_full |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance |
| title_fullStr |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance |
| title_full_unstemmed |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance |
| title_sort |
The influence of oxytocin and prolactin during a first-episode of psychosis: the implication of sex differences, clinical features and cognitive performance |
| author |
Hidalgo Figueroa, María |
| author_facet |
Hidalgo Figueroa, María Salazar, Alejandro Romero López-Alberca, Cristina MacDowell, Karina S. García Bueno, Borja Bioque Alcázar, Miquel Bernardo Vilamitjana, Mercè Parellada, Mara González-Pinto, Ana García Portilla, María Paz Lobo, Antonio Rodriguez Jimenez, Roberto Berrocoso, Esther Leza, Juan Carlos |
| author_role |
author |
| author2 |
Salazar, Alejandro Romero López-Alberca, Cristina MacDowell, Karina S. García Bueno, Borja Bioque Alcázar, Miquel Bernardo Vilamitjana, Mercè Parellada, Mara González-Pinto, Ana García Portilla, María Paz Lobo, Antonio Rodriguez Jimenez, Roberto Berrocoso, Esther Leza, Juan Carlos |
| author2_role |
author author author author author author author author author author author author author |
| topic |
Prolactina Psicosi Cognició Oxitocina Diferències entre sexes (Psicologia) Prolactin Psychoses Cognition Oxytocin Sex differences (Psychology) |
| topic_facet |
Prolactina Psicosi Cognició Oxitocina Diferències entre sexes (Psicologia) Prolactin Psychoses Cognition Oxytocin Sex differences (Psychology) |
| description |
Background: Approximately 3% of the population suffers a first episode of psychosis (FEP), and a high percentage of these patients subsequently relapse. Because the clinical course following a FEP is hard to predict, it is of interest to identify cognitive and biological markers that will help improve the diagnosis, treatment, and outcome of such events and to define new therapeutic targets. Here we analyzed the plasma oxytocin and prolactin levels during an FEP, assessing their correlation with clinical and cognitive features. Methods: The oxytocin and prolactin in plasma was measured in 120 FEP patients and 106 healthy controls, all of whom were subjected to a clinical and neuropsychological assessment. Most patients were under antipsychotics. Statistical analyses aimed to identify factors associated with the FEP and to search for associations between the variables. This study is preliminary and exploratory because the P-values were not corrected for multiple comparisons. Results: FEP patients had less oxytocin, more prolactin, and a poor premorbid IQ, and they performed worse in sustained attention. Male patients with higher prolactin levels experienced more severe psychotic symptoms and required higher doses of antipsychotics. Low oxytocin was associated with poor sustained attention in women, whereas low oxytocin and high prolactin in men correlated with better performance in sustained attention. Conclusion: Low oxytocin, high prolactin, and poor premorbid IQ and sustained attention are factors associated with an FEP, representing potential therapeutic targets in these patients. These biological factors and cognitive domains might play an important role during a FEP, which could help us to develop new strategies that improve the outcomes of this disorder and that should perhaps be gender specific. |
| publishDate |
2022 |
| format |
article |
| status_str |
publishedVersion |
| url |
https://hdl.handle.net/2445/209205 |
| eu_rights_str_mv |
openAccess |
| publisher |
Oxford University Press |
| institution |
Universidad de Barcelona |
| collection |
Dipòsit Digital de la UB |
| reponame_str |
Dipòsit Digital de la UB |
| instname_str |
Universidad de Barcelona |
| _version_ |
1878435007113986048 |
| publishDateSort |
2022 |
| author_browse |
Bernardo Vilamitjana, Mercè Berrocoso, Esther Bioque Alcázar, Miquel García Bueno, Borja García Portilla, María Paz González-Pinto, Ana Hidalgo Figueroa, María Leza, Juan Carlos Lobo, Antonio MacDowell, Karina S. Parellada, Mara Rodriguez Jimenez, Roberto Romero López-Alberca, Cristina Salazar, Alejandro |
| publisherStr |
Oxford University Press |
| score |
6,924472 |