Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain
Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2017 |
| País: | España |
| Institución: | Universidad Autónoma de Madrid |
| Repositorio: | Biblos-e Archivo. Repositorio Institucional de la UAM |
| Idioma: | inglés |
| OAI Identifier: | oai:repositorio.uam.es:10486/680250 |
| Acceso en línea: | http://hdl.handle.net/10486/680250 https://dx.doi.org/10.3389/fmicb.2017.00888 |
| Access Level: | acceso abierto |
| Palabra clave: | Bacterial infections Chronic infection Colorectal neoplasm Helicobacter pylori Multiplex serology Non-infectious diseases Medicina |
| id |
ES_71d2aee3fb511ade45c911a4e7befb8c |
|---|---|
| oai_identifier_str |
oai:repositorio.uam.es:10486/680250 |
| network_acronym_str |
ES |
| network_name_str |
España |
| spelling |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain Fernández de Larrea-Baz, Nerea Michel, Angelika Romero, Beatriz Pérez-Gómez, Beatriz Moreno, Víctor Martín, Vicente Dierssen-Sotos, Trinidad Jiménez-Moleón, José J. Castilla, Jesús Tardón, Adonina Ruiz, Irune Peiró, Rosana Tejada, Antonio Chirlaque, María D. Butt, Julia A. Olmedo-Requena, Rocío Gómez-Acebo, Inés Linares, Pedro Boldo, Elena Castells, Antoni Pawlita, Michael Castaño-Vinyals, Gemma Kogevinas, Manolis Sanjosé, Silvia de Pollán Santamaría, Marina Anunciación Campo, Rosa del Waterboer, Tim Aragonés, Nuria Bacterial infections Chronic infection Colorectal neoplasm Helicobacter pylori Multiplex serology Non-infectious diseases Medicina Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to =4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagd showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified The study was supported by the “Acción Transversal del Cáncer,” approved on the Spanish Ministry Council on the 11th October 2007, by the Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), by the Instituto de Salud Carlos III grants, co-funded by FEDER funds—a way to build Europe—(grants PI08/1770, PI09/0773, PI09/1286, PI09/1903, PI09/2078, PI09/1662, PI11/01403, PI14/00613, PI14/01219, and PI15/00069), by the Fundación Marqués de Valdecilla (grant API 10/09), by Catalan Government DURSI (grants 2014SGR647 and 2014SGR756), by the Junta de Castilla y León (grant LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (grant 2009-S0143), by the Regional Government of the Basque Country, and by the Conselleria de Sanitat of the Generalitat Valenciana (grant AP061/10). Frontiers Media http://hdl.handle.net/10486/680250 https://dx.doi.org/10.3389/fmicb.2017.00888 |
| title |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain |
| spellingShingle |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain Fernández de Larrea-Baz, Nerea Bacterial infections Chronic infection Colorectal neoplasm Helicobacter pylori Multiplex serology Non-infectious diseases Medicina |
| title_short |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain |
| title_full |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain |
| title_fullStr |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain |
| title_full_unstemmed |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain |
| title_sort |
Helicobacter pylori antibody reactivities and colorectal cancer risk in a case-control study in Spain |
| author |
Fernández de Larrea-Baz, Nerea |
| author_facet |
Fernández de Larrea-Baz, Nerea Michel, Angelika Romero, Beatriz Pérez-Gómez, Beatriz Moreno, Víctor Martín, Vicente Dierssen-Sotos, Trinidad Jiménez-Moleón, José J. Castilla, Jesús Tardón, Adonina Ruiz, Irune Peiró, Rosana Tejada, Antonio Chirlaque, María D. Butt, Julia A. Olmedo-Requena, Rocío Gómez-Acebo, Inés Linares, Pedro Boldo, Elena Castells, Antoni Pawlita, Michael Castaño-Vinyals, Gemma Kogevinas, Manolis Sanjosé, Silvia de Pollán Santamaría, Marina Anunciación Campo, Rosa del Waterboer, Tim Aragonés, Nuria |
| author_role |
author |
| author2 |
Michel, Angelika Romero, Beatriz Pérez-Gómez, Beatriz Moreno, Víctor Martín, Vicente Dierssen-Sotos, Trinidad Jiménez-Moleón, José J. Castilla, Jesús Tardón, Adonina Ruiz, Irune Peiró, Rosana Tejada, Antonio Chirlaque, María D. Butt, Julia A. Olmedo-Requena, Rocío Gómez-Acebo, Inés Linares, Pedro Boldo, Elena Castells, Antoni Pawlita, Michael Castaño-Vinyals, Gemma Kogevinas, Manolis Sanjosé, Silvia de Pollán Santamaría, Marina Anunciación Campo, Rosa del Waterboer, Tim Aragonés, Nuria |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| topic |
Bacterial infections Chronic infection Colorectal neoplasm Helicobacter pylori Multiplex serology Non-infectious diseases Medicina |
| topic_facet |
Bacterial infections Chronic infection Colorectal neoplasm Helicobacter pylori Multiplex serology Non-infectious diseases Medicina |
| description |
Background: Several studies have suggested that Helicobacter pylori (H. pylori) infection is a risk factor for colorectal cancer (CRC), while others have not confirmed this hypothesis. This work aimed to assess the relation of CRC with H. pylori seropositivity and with seropositivity to 16 H. pylori proteins, in the MultiCase-Control study, MCC-Spain. Methods: MCC-Spain is a multicase-control study carried out in Spain from 2008 to 2013. In total, 2,140 histologically-confirmed incident CRC cases and 4,098 population-based controls were recruited. Controls were frequency-matched by sex, age, and province. Epidemiological data were collected through a questionnaire fulfilled by face-to-face interviews and a self-administered food-frequency questionnaire. Seroreactivities against 16 H. pylori proteins were determined in 1,488 cases and 2,495 controls using H. pylori multiplex serology. H. pylori seropositivity was defined as positivity to =4 proteins. Multivariable logistic regression mixed models were used to estimate odds ratios (OR) and 95% confidence intervals (CI). Results: H. pylori seropositivity was not associated with increased CRC risk (OR = 0.91; 95% CI: 0.71-1.16). Among H. pylori seropositive subjects, seropositivity to Cagd showed a lower CRC risk, and risk decreased with increasing number of proteins seropositive. Seropositivity to the most recognized virulence factors, CagA and VacA, was not associated with a higher CRC risk. No statistically significant heterogeneity was identified among tumor sites, although inverse relations were stronger for left colon cancer. An interaction with age and sex was found: H. pylori seropositivity was associated with a lower CRC risk in men younger than 65 and with a higher risk in older women. Conclusions: Our results suggest that neither H. pylori seropositivity, nor seropositivity to the virulence factor CagA are associated with a higher CRC risk. A possible effect modification by age and sex was identified |
| publishDate |
2017 |
| format |
article |
| url |
http://hdl.handle.net/10486/680250 https://dx.doi.org/10.3389/fmicb.2017.00888 |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| publisher |
Frontiers Media |
| institution |
Universidad Autónoma de Madrid |
| collection |
Biblos-e Archivo. Repositorio Institucional de la UAM |
| reponame_str |
Biblos-e Archivo. Repositorio Institucional de la UAM |
| instname_str |
Universidad Autónoma de Madrid |
| _version_ |
1878436299573035008 |
| publishDateSort |
2017 |
| author_browse |
Aragonés, Nuria Boldo, Elena Butt, Julia A. Campo, Rosa del Castaño-Vinyals, Gemma Castells, Antoni Castilla, Jesús Chirlaque, María D. Dierssen-Sotos, Trinidad Fernández de Larrea-Baz, Nerea Gómez-Acebo, Inés Jiménez-Moleón, José J. Kogevinas, Manolis Linares, Pedro Martín, Vicente Michel, Angelika Moreno, Víctor Olmedo-Requena, Rocío Pawlita, Michael Peiró, Rosana Pollán Santamaría, Marina Anunciación Pérez-Gómez, Beatriz Romero, Beatriz Ruiz, Irune Sanjosé, Silvia de Tardón, Adonina Tejada, Antonio Waterboer, Tim |
| publisherStr |
Frontiers Media |
| score |
6.9303427 |