Absorption and metabolism of yerba mate phenolic compounds in humans

Bioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with ra...

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Autores: Gómez Juaristi, Miren, Martínez López, Sara, Sarriá, Beatriz, Bravo-Clemente, Laura, Mateos, Raquel
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2018
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/170810
Acceso en línea:http://hdl.handle.net/10261/170810
Access Level:acceso abierto
Palabra clave:Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
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spelling Absorption and metabolism of yerba mate phenolic compounds in humans Gómez Juaristi, Miren Martínez López, Sara Sarriá, Beatriz Bravo-Clemente, Laura Mateos, Raquel Hydroxycinnamate derivatives Flavonols Bioavailability Colonic microbiota LC-MS-QToF Yerba mate Bioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with rapid appearance and clearance in plasma indicative of small intestinal absorption. These compounds amounted to 13.1% of the urinary metabolites. Delayed absorption of dihydrocaffeic, dihydroferulic and dihydrocoumaric acids and their phase II metabolites, in addition to feruloylglycine, pointed to their microbial origin and colonic absorption, accounting for 81.0% of excreted metabolites. Phase II flavonol metabolites (0.2%) derived mainly from rutin after colonic transformation and absorption were also detected. Additionally, dihydroferuloyl-, dihydrocaffeoyl- and dihydrocoumaroylquinic acids (5.7%) were identified, showing the most delayed kinetics. Total phenolic excretion (147.6 μmol) corresponded to 13.2% of ingested phenols. In conclusion, yerba mate polyphenols are partially bioavailable and extensively metabolized, mainly by the colonic microbiota. We also are grateful to the Spanish Ministry of Economy and Competitivity (MINECO-FEDER) for financial support (projects AGL2010-18269 and AGL2015-69986-R). S.M.-L. was a predoctoral fellow of the JAE Program (JAEPre097) co-funded by CSIC and the European Social Fund. M. G.-J. was a predoctoral FPI fellow (BES2008-007138) of the Spanish Ministry of Science and Innovation. Peer Reviewed Elsevier http://hdl.handle.net/10261/170810
title Absorption and metabolism of yerba mate phenolic compounds in humans
spellingShingle Absorption and metabolism of yerba mate phenolic compounds in humans
Gómez Juaristi, Miren
Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
title_short Absorption and metabolism of yerba mate phenolic compounds in humans
title_full Absorption and metabolism of yerba mate phenolic compounds in humans
title_fullStr Absorption and metabolism of yerba mate phenolic compounds in humans
title_full_unstemmed Absorption and metabolism of yerba mate phenolic compounds in humans
title_sort Absorption and metabolism of yerba mate phenolic compounds in humans
author Gómez Juaristi, Miren
author_facet Gómez Juaristi, Miren
Martínez López, Sara
Sarriá, Beatriz
Bravo-Clemente, Laura
Mateos, Raquel
author_role author
author2 Martínez López, Sara
Sarriá, Beatriz
Bravo-Clemente, Laura
Mateos, Raquel
author2_role author
author
author
author
topic Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
topic_facet Hydroxycinnamate derivatives
Flavonols
Bioavailability
Colonic microbiota
LC-MS-QToF
Yerba mate
description Bioavailability of yerba mate phenolic compounds was assessed in healthy humans. More than 34 metabolites were identified in biological fluids, mainly sulfated conjugates of caffeic and ferulic/isoferulic acids, in addition to non-metabolized caffeoyl-, feruloyl- and p-coumaroilquinic acids, with rapid appearance and clearance in plasma indicative of small intestinal absorption. These compounds amounted to 13.1% of the urinary metabolites. Delayed absorption of dihydrocaffeic, dihydroferulic and dihydrocoumaric acids and their phase II metabolites, in addition to feruloylglycine, pointed to their microbial origin and colonic absorption, accounting for 81.0% of excreted metabolites. Phase II flavonol metabolites (0.2%) derived mainly from rutin after colonic transformation and absorption were also detected. Additionally, dihydroferuloyl-, dihydrocaffeoyl- and dihydrocoumaroylquinic acids (5.7%) were identified, showing the most delayed kinetics. Total phenolic excretion (147.6 μmol) corresponded to 13.2% of ingested phenols. In conclusion, yerba mate polyphenols are partially bioavailable and extensively metabolized, mainly by the colonic microbiota.
publishDate 2018
format article
status_str acceptedVersion
url http://hdl.handle.net/10261/170810
eu_rights_str_mv openAccess
publisher Elsevier
institution Consejo Superior de Investigaciones Científicas (CSIC)
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
_version_ 1878436491380654080
publishDateSort 2018
author_browse Bravo-Clemente, Laura
Gómez Juaristi, Miren
Martínez López, Sara
Mateos, Raquel
Sarriá, Beatriz
publisherStr Elsevier
score 6,924472

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