Microvesicles: ROS scavengers and ROS producers
This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly...
| Autores: | , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2019 |
| País: | España |
| Institución: | Universidad de Alcalá (UAH) |
| Repositorio: | e_Buah Biblioteca Digital Universidad de Alcalá |
| Idioma: | inglés |
| OAI Identifier: | oai:ebuah.uah.es:10017/64115 |
| Acceso en línea: | http://hdl.handle.net/10017/64115 https://dx.doi.org/10.1080/20013078.2019.1626654 |
| Access Level: | acceso abierto |
| Palabra clave: | Extracellular vesicles Microvesicles Reactive oxygen species Medicina Medicine |
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oai:ebuah.uah.es:10017/64115 |
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Microvesicles: ROS scavengers and ROS producers Bodega Magro, Guillermo|||0000-0003-1469-3242 Alique Aguilar, Matilde|||0000-0002-7912-1133 Puebla Jiménez, Lilian|||0000-0002-0681-3235 Carracedo, Julia Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X Extracellular vesicles Microvesicles Reactive oxygen species Medicina Medicine This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly and/or indirectly modify the ROS content in the extra- as well as the intracellular compartments. In this regard, microvesicles contain a pro-oxidant or antioxidant machinery that may produce or scavenge ROS: direct effect. This mechanism is especially suitable for eliminating ROS in the extracellular compartment. Endothelial microvesicles, in particular, contain a specific and well-developed antioxidant machinery. On the other hand, the molecules included in microvesicles can modify (activate or inhibit) ROS metabolism in their target cells: indirect effect. This can be achieved by the incorporation into the cells of ROS metabolic enzymes included in the microvesicles, or by the regulation of signaling pathways involved in ROS metabolism. Proteins, as well as miRNAs, are involved in this last effect. http://hdl.handle.net/10017/64115 https://dx.doi.org/10.1080/20013078.2019.1626654 |
| title |
Microvesicles: ROS scavengers and ROS producers |
| spellingShingle |
Microvesicles: ROS scavengers and ROS producers Bodega Magro, Guillermo|||0000-0003-1469-3242 Extracellular vesicles Microvesicles Reactive oxygen species Medicina Medicine |
| title_short |
Microvesicles: ROS scavengers and ROS producers |
| title_full |
Microvesicles: ROS scavengers and ROS producers |
| title_fullStr |
Microvesicles: ROS scavengers and ROS producers |
| title_full_unstemmed |
Microvesicles: ROS scavengers and ROS producers |
| title_sort |
Microvesicles: ROS scavengers and ROS producers |
| author |
Bodega Magro, Guillermo|||0000-0003-1469-3242 |
| author_facet |
Bodega Magro, Guillermo|||0000-0003-1469-3242 Alique Aguilar, Matilde|||0000-0002-7912-1133 Puebla Jiménez, Lilian|||0000-0002-0681-3235 Carracedo, Julia Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X |
| author_role |
author |
| author2 |
Alique Aguilar, Matilde|||0000-0002-7912-1133 Puebla Jiménez, Lilian|||0000-0002-0681-3235 Carracedo, Julia Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X |
| author2_role |
author author author author |
| topic |
Extracellular vesicles Microvesicles Reactive oxygen species Medicina Medicine |
| topic_facet |
Extracellular vesicles Microvesicles Reactive oxygen species Medicina Medicine |
| description |
This review analyzes the relationship between microvesicles and reactive oxygen species (ROS). This relationship is bidirectional; on the one hand, the number and content of microvesicles produced by the cells are affected by oxidative stress conditions; on the other hand, microvesicles can directly and/or indirectly modify the ROS content in the extra- as well as the intracellular compartments. In this regard, microvesicles contain a pro-oxidant or antioxidant machinery that may produce or scavenge ROS: direct effect. This mechanism is especially suitable for eliminating ROS in the extracellular compartment. Endothelial microvesicles, in particular, contain a specific and well-developed antioxidant machinery. On the other hand, the molecules included in microvesicles can modify (activate or inhibit) ROS metabolism in their target cells: indirect effect. This can be achieved by the incorporation into the cells of ROS metabolic enzymes included in the microvesicles, or by the regulation of signaling pathways involved in ROS metabolism. Proteins, as well as miRNAs, are involved in this last effect. |
| publishDate |
2019 |
| format |
article |
| url |
http://hdl.handle.net/10017/64115 https://dx.doi.org/10.1080/20013078.2019.1626654 |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| institution |
Universidad de Alcalá (UAH) |
| collection |
e_Buah Biblioteca Digital Universidad de Alcalá |
| reponame_str |
e_Buah Biblioteca Digital Universidad de Alcalá |
| instname_str |
Universidad de Alcalá (UAH) |
| _version_ |
1878436735844614144 |
| publishDateSort |
2019 |
| author_browse |
Alique Aguilar, Matilde|||0000-0002-7912-1133 Bodega Magro, Guillermo|||0000-0003-1469-3242 Carracedo, Julia Puebla Jiménez, Lilian|||0000-0002-0681-3235 Ramírez Chamond, Manuel Rafael|||0000-0003-4598-339X |
| score |
6,924472 |