Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test

Introduction: Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials increase. The NEMA image quality test is often considered for the evaluation o...

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Autores: Vallot, Delphine, Ponti, Elena De, Morzenti, Sabrina, Gramek, Anna, Pieczonka, Anna, Reynés-Llompart, Gabriel, Siennicki, Jakub, Deak, Paul, Dutta, Chiranjib, Uribe, Jorge, Caselles, Olivier
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/173108
Acceso en línea:https://hdl.handle.net/2445/173108
Access Level:acceso abierto
Palabra clave:Oncologia
Marcadors bioquímics
Oncology
Biochemical markers
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spelling Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test Vallot, Delphine Ponti, Elena De Morzenti, Sabrina Gramek, Anna Pieczonka, Anna Reynés-Llompart, Gabriel Siennicki, Jakub Deak, Paul Dutta, Chiranjib Uribe, Jorge Caselles, Olivier Oncologia Marcadors bioquímics Oncology Biochemical markers Introduction: Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials increase. The NEMA image quality test is often considered for the evaluation of quantitation and is more accurate with a radioactive solid phantom that reduces variability. The goal of this project is to determine the level of variability among imaging centers if acquisition and imaging protocol parameters are left to the center's preference while all other parameters are fixed including the scanner type. Methods: A NEMA-IQ phantom filled with radioactive Ge-68 solid resin was imaged in five clinical sites throughout Europe. Sites reconstructed data with OSEM and BSREM algorithms applying the sites' clinical parameters. Images were analyzed according with the NEMA-NU2-2012 standard using the manufacturer-provided NEMA tools to calculate contrast recovery (CR) and background variability (BV) for each sphere and the lung error (LE) estimation. In addition, a F-18-filled NEMA-IQ phantom was also evaluated to obtain a gauge for variability among centers when the sites were provided with identical specific instructions for acquisition and reconstruction protocol (the aggregate of data from 12 additional sites is presented). Results: The data using the Ge-68 solid phantom showed no statistical differences among different sites, proving a very good reproducibility among the PET center models even if dispersion of data is higher with OSEM compared to BSREM. Furthermore, BSREM shows better CR and comparable BV, while LE is slightly reduced. Two centers exhibit significant differences in CR and BV values for the F-18 NEMA NU2-2012 experiments; these outlier results are explained. Conclusion: The same PET system type from the various sites produced similar quantitative results, despite allowing each site to choose their clinical protocols with no restriction on data acquisition and reconstruction parameters. BSREM leads to lower dispersion of quantitative data among different sites. A solid radioactive phantom may be recommended to qualify the sites to perform quantitative imaging. Springer https://hdl.handle.net/2445/173108
title Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
spellingShingle Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
Vallot, Delphine
Oncologia
Marcadors bioquímics
Oncology
Biochemical markers
title_short Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
title_full Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
title_fullStr Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
title_full_unstemmed Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
title_sort Evaluation of PET quantitation accuracy among multiple discovery IQ PET/CT systems via NEMA image quality test
author Vallot, Delphine
author_facet Vallot, Delphine
Ponti, Elena De
Morzenti, Sabrina
Gramek, Anna
Pieczonka, Anna
Reynés-Llompart, Gabriel
Siennicki, Jakub
Deak, Paul
Dutta, Chiranjib
Uribe, Jorge
Caselles, Olivier
author_role author
author2 Ponti, Elena De
Morzenti, Sabrina
Gramek, Anna
Pieczonka, Anna
Reynés-Llompart, Gabriel
Siennicki, Jakub
Deak, Paul
Dutta, Chiranjib
Uribe, Jorge
Caselles, Olivier
author2_role author
author
author
author
author
author
author
author
author
author
topic Oncologia
Marcadors bioquímics
Oncology
Biochemical markers
topic_facet Oncologia
Marcadors bioquímics
Oncology
Biochemical markers
description Introduction: Quantitative imaging biomarkers are becoming usual in oncology for assessing therapy response. The harmonization of image quantitation reporting has become of utmost importance due to the multi-center trials increase. The NEMA image quality test is often considered for the evaluation of quantitation and is more accurate with a radioactive solid phantom that reduces variability. The goal of this project is to determine the level of variability among imaging centers if acquisition and imaging protocol parameters are left to the center's preference while all other parameters are fixed including the scanner type. Methods: A NEMA-IQ phantom filled with radioactive Ge-68 solid resin was imaged in five clinical sites throughout Europe. Sites reconstructed data with OSEM and BSREM algorithms applying the sites' clinical parameters. Images were analyzed according with the NEMA-NU2-2012 standard using the manufacturer-provided NEMA tools to calculate contrast recovery (CR) and background variability (BV) for each sphere and the lung error (LE) estimation. In addition, a F-18-filled NEMA-IQ phantom was also evaluated to obtain a gauge for variability among centers when the sites were provided with identical specific instructions for acquisition and reconstruction protocol (the aggregate of data from 12 additional sites is presented). Results: The data using the Ge-68 solid phantom showed no statistical differences among different sites, proving a very good reproducibility among the PET center models even if dispersion of data is higher with OSEM compared to BSREM. Furthermore, BSREM shows better CR and comparable BV, while LE is slightly reduced. Two centers exhibit significant differences in CR and BV values for the F-18 NEMA NU2-2012 experiments; these outlier results are explained. Conclusion: The same PET system type from the various sites produced similar quantitative results, despite allowing each site to choose their clinical protocols with no restriction on data acquisition and reconstruction parameters. BSREM leads to lower dispersion of quantitative data among different sites. A solid radioactive phantom may be recommended to qualify the sites to perform quantitative imaging.
publishDate 2020
format article
status_str publishedVersion
url https://hdl.handle.net/2445/173108
eu_rights_str_mv openAccess
publisher Springer
institution Universidad de Barcelona
collection Dipòsit Digital de la UB
reponame_str Dipòsit Digital de la UB
instname_str Universidad de Barcelona
_version_ 1878436839293976576
publishDateSort 2020
author_browse Caselles, Olivier
Deak, Paul
Dutta, Chiranjib
Gramek, Anna
Morzenti, Sabrina
Pieczonka, Anna
Ponti, Elena De
Reynés-Llompart, Gabriel
Siennicki, Jakub
Uribe, Jorge
Vallot, Delphine
publisherStr Springer
score 6,924472

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