BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity
The development of new biomaterials for musculoskeletal tissue repair is currently an important branch in biomedicine research. The approach presented here is centered around the development of a prototypic synthetic glycerogel scaffold for bone regeneration, which simultaneously features therapeuti...
| Autores: | , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2024 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:308219 |
| Acceso en línea: | https://ddd.uab.cat/record/308219 https://dx.doi.org/urn:doi:10.3390/gels10100631 |
| Access Level: | acceso abierto |
| Palabra clave: | Glycerogel Cellulose Biomof Composite Scaffold Tissue repair |
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ES_80ef8e30760fdede6944704dc8d643ef |
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| oai_identifier_str |
oai:ddd.uab.cat:308219 |
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ES |
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España |
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BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity Perspective in Bone Tissue Repair Rosado, Albert|||0000-0003-3222-9566 Borrás Caballero, Alejandro|||0000-0002-0725-421X Sánchez-Soto, Miguel|||0000-0002-0023-5059 Labíková, Magdaléna Hettegger, Hubert|||0000-0002-9343-5673 Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553 Rojo, Luís|||0000-0001-6334-6736 García-Fernández, Luis|||0000-0002-4179-2556 Aguilar, María Rosa|||0000-0001-7395-5754 Liebner, Falk|||0000-0002-8244-8153 Lopez-Periago, Ana M.|||0000-0002-3777-3205 Ayllón, José A.|||0000-0001-7965-7424 Domingo, Concepción|||0000-0001-7857-2760 Glycerogel Cellulose Biomof Composite Scaffold Tissue repair The development of new biomaterials for musculoskeletal tissue repair is currently an important branch in biomedicine research. The approach presented here is centered around the development of a prototypic synthetic glycerogel scaffold for bone regeneration, which simultaneously features therapeutic activity. The main novelty of this work lies in the combination of an open meso and macroporous nanocrystalline cellulose (NCC)-based glycerogel with a fully biocompatible microporous bioMOF system (CaSyr-1) composed of calcium ions and syringic acid. The bioMOF framework is further impregnated with a third bioactive component, i.e., ibuprofen (ibu), to generate a multifold bioactive system. The integrated CaSyr-1(ibu) serves as a reservoir for bioactive compounds delivery, while the NCC scaffold is the proposed matrix for cell ingrowth, proliferation and differentiation. The measured drug delivery profiles, studied in a phosphate-buffered saline solution at 310 K, indicate that the bioactive components are released concurrently with bioMOF dissolution after ca. 30 min following a pseudo-first-order kinetic model. Furthermore, according to the semi-empirical Korsmeyer-Peppas kinetic model, this release is governed by a case-II mechanism, suggesting that the molecular transport is influenced by the relaxation of the NCC matrix. Preliminary in vitro results denote that the initial high concentration of glycerol in the NCC scaffold can be toxic in direct contact with human osteoblasts (HObs). However, when the excess of glycerol is diluted in the system (after the second day of the experiment), the direct and indirect assays confirm full biocompatibility and suitability for HOb proliferation. https://ddd.uab.cat/record/308219 https://dx.doi.org/urn:doi:10.3390/gels10100631 |
| title |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity |
| spellingShingle |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity Rosado, Albert|||0000-0003-3222-9566 Glycerogel Cellulose Biomof Composite Scaffold Tissue repair |
| title_short |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity |
| title_full |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity |
| title_fullStr |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity |
| title_full_unstemmed |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity |
| title_sort |
BioMOF@cellulose Glycerogel Scaffold with Multifold Bioactivity |
| author |
Rosado, Albert|||0000-0003-3222-9566 |
| author_facet |
Rosado, Albert|||0000-0003-3222-9566 Borrás Caballero, Alejandro|||0000-0002-0725-421X Sánchez-Soto, Miguel|||0000-0002-0023-5059 Labíková, Magdaléna Hettegger, Hubert|||0000-0002-9343-5673 Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553 Rojo, Luís|||0000-0001-6334-6736 García-Fernández, Luis|||0000-0002-4179-2556 Aguilar, María Rosa|||0000-0001-7395-5754 Liebner, Falk|||0000-0002-8244-8153 Lopez-Periago, Ana M.|||0000-0002-3777-3205 Ayllón, José A.|||0000-0001-7965-7424 Domingo, Concepción|||0000-0001-7857-2760 |
| author_role |
author |
| author2 |
Borrás Caballero, Alejandro|||0000-0002-0725-421X Sánchez-Soto, Miguel|||0000-0002-0023-5059 Labíková, Magdaléna Hettegger, Hubert|||0000-0002-9343-5673 Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553 Rojo, Luís|||0000-0001-6334-6736 García-Fernández, Luis|||0000-0002-4179-2556 Aguilar, María Rosa|||0000-0001-7395-5754 Liebner, Falk|||0000-0002-8244-8153 Lopez-Periago, Ana M.|||0000-0002-3777-3205 Ayllón, José A.|||0000-0001-7965-7424 Domingo, Concepción|||0000-0001-7857-2760 |
| author2_role |
author author author author author author author author author author author author |
| topic |
Glycerogel Cellulose Biomof Composite Scaffold Tissue repair |
| topic_facet |
Glycerogel Cellulose Biomof Composite Scaffold Tissue repair |
| description |
The development of new biomaterials for musculoskeletal tissue repair is currently an important branch in biomedicine research. The approach presented here is centered around the development of a prototypic synthetic glycerogel scaffold for bone regeneration, which simultaneously features therapeutic activity. The main novelty of this work lies in the combination of an open meso and macroporous nanocrystalline cellulose (NCC)-based glycerogel with a fully biocompatible microporous bioMOF system (CaSyr-1) composed of calcium ions and syringic acid. The bioMOF framework is further impregnated with a third bioactive component, i.e., ibuprofen (ibu), to generate a multifold bioactive system. The integrated CaSyr-1(ibu) serves as a reservoir for bioactive compounds delivery, while the NCC scaffold is the proposed matrix for cell ingrowth, proliferation and differentiation. The measured drug delivery profiles, studied in a phosphate-buffered saline solution at 310 K, indicate that the bioactive components are released concurrently with bioMOF dissolution after ca. 30 min following a pseudo-first-order kinetic model. Furthermore, according to the semi-empirical Korsmeyer-Peppas kinetic model, this release is governed by a case-II mechanism, suggesting that the molecular transport is influenced by the relaxation of the NCC matrix. Preliminary in vitro results denote that the initial high concentration of glycerol in the NCC scaffold can be toxic in direct contact with human osteoblasts (HObs). However, when the excess of glycerol is diluted in the system (after the second day of the experiment), the direct and indirect assays confirm full biocompatibility and suitability for HOb proliferation. |
| publishDate |
2024 |
| format |
article |
| url |
https://ddd.uab.cat/record/308219 https://dx.doi.org/urn:doi:10.3390/gels10100631 |
| language |
eng |
| eu_rights_str_mv |
openAccess |
| institution |
Universitat Autònoma de Barcelona |
| collection |
Dipòsit Digital de Documents de la UAB |
| reponame_str |
Dipòsit Digital de Documents de la UAB |
| instname_str |
Universitat Autònoma de Barcelona |
| _version_ |
1878437096423686144 |
| publishDateSort |
2024 |
| author_browse |
Aguilar, María Rosa|||0000-0001-7395-5754 Ayllón, José A.|||0000-0001-7965-7424 Borrás Caballero, Alejandro|||0000-0002-0725-421X Domingo, Concepción|||0000-0001-7857-2760 García-Fernández, Luis|||0000-0002-4179-2556 Hettegger, Hubert|||0000-0002-9343-5673 Labíková, Magdaléna Liebner, Falk|||0000-0002-8244-8153 Lopez-Periago, Ana M.|||0000-0002-3777-3205 Ramírez-Jiménez, Rosa Ana|||0000-0001-7563-2553 Rojo, Luís|||0000-0001-6334-6736 Rosado, Albert|||0000-0003-3222-9566 Sánchez-Soto, Miguel|||0000-0002-0023-5059 |
| score |
6,9303427 |