Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache.
Background: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression...
| Autores: | , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/194711 |
| Acceso en línea: | https://hdl.handle.net/2445/194711 |
| Access Level: | acceso abierto |
| Palabra clave: | Migranya Cefalàlgia Migraine Headache |
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oai:recercat.cat:2445/194711 |
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España |
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Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. Siewert, Katherine M. Klarin, Derek Damrauer, Scott M. Chang, Kyong-Mi Tsao, Philip S. Assimes, Themistocles L. Smith, George Davey Voight, Benjamin F. The International Headache Genetics Consortium Cormand Rifà, Bru Migranya Cefalàlgia Migraine Headache Background: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available. Results: We report multiple phenotypes with genetic correlation (P < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine. Conclusions: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci. Oxford University Press https://hdl.handle.net/2445/194711 |
| title |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. |
| spellingShingle |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. Siewert, Katherine M. Migranya Cefalàlgia Migraine Headache |
| title_short |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. |
| title_full |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. |
| title_fullStr |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. |
| title_full_unstemmed |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. |
| title_sort |
Cross-trait analyses with migraine reveal widespread pleiotropy and suggest a vascular component to migraine headache. |
| author |
Siewert, Katherine M. |
| author_facet |
Siewert, Katherine M. Klarin, Derek Damrauer, Scott M. Chang, Kyong-Mi Tsao, Philip S. Assimes, Themistocles L. Smith, George Davey Voight, Benjamin F. The International Headache Genetics Consortium Cormand Rifà, Bru |
| author_role |
author |
| author2 |
Klarin, Derek Damrauer, Scott M. Chang, Kyong-Mi Tsao, Philip S. Assimes, Themistocles L. Smith, George Davey Voight, Benjamin F. The International Headache Genetics Consortium Cormand Rifà, Bru |
| author2_role |
author author author author author author author author author |
| topic |
Migranya Cefalàlgia Migraine Headache |
| topic_facet |
Migranya Cefalàlgia Migraine Headache |
| description |
Background: Nearly a fifth of the world's population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods: To further elucidate these factors, we conducted a genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between migraine headache and 47 traits from the UK Biobank. We then tested for possible causality between these phenotypes and migraine, using Mendelian randomization. In addition, we attempted replication of our findings in an independent genome-wide association study (GWAS) when available. Results: We report multiple phenotypes with genetic correlation (P < 1.06 × 10-3) with migraine, including heart disease, type 2 diabetes, lipid levels, blood pressure, autoimmune and psychiatric phenotypes. In particular, we find evidence that blood pressure directly contributes to migraine and explains a previously suggested causal relationship between calcium and migraine. Conclusions: This is the largest genetic correlation analysis of migraine headache to date, both in terms of migraine GWAS sample size and the number of phenotypes tested. We find that migraine has a shared genetic basis with a large number of traits, indicating pervasive pleiotropy at migraine-associated loci. |
| publishDate |
2020 |
| format |
article |
| status_str |
publishedVersion |
| url |
https://hdl.handle.net/2445/194711 |
| eu_rights_str_mv |
openAccess |
| publisher |
Oxford University Press |
| institution |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| _version_ |
1878437307441217536 |
| publishDateSort |
2020 |
| author_browse |
Assimes, Themistocles L. Chang, Kyong-Mi Cormand Rifà, Bru Damrauer, Scott M. Klarin, Derek Siewert, Katherine M. Smith, George Davey The International Headache Genetics Consortium Tsao, Philip S. Voight, Benjamin F. |
| publisherStr |
Oxford University Press |
| score |
6.9303427 |