Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation

Primary graft dysfunction (PGD) remains a major cause of early morbidity and mortality after a heart transplant (HTx). Understanding the donor-related mechanisms involved may help improve organ selection and post-HTx outcomes. This study aimed to explore the association between the donor serum bioma...

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Autores: Herrador, Lorena, González-Costello, José, Niubo Bosch, Jordi, Calatayud Samper, Laura, Maestro Benedicto, Alba, Farrero Torres, Marta, Blasco Peiró, Teresa, Almenar Bonet, Luis, Blázquez Bermejo, Zorba, Garrido Bravo, Iris, Gran Ipiña, Ferran, Grande Trillo, Antonio, Manito, Nicolas, Moreno González, Gabriel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224333
Acceso en línea:https://hdl.handle.net/2445/224333
Access Level:acceso abierto
Palabra clave:Inflamació
Apoptosi
Trasplantament cardíac
Inflammation
Apoptosis
Heart transplantation
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spelling Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation Herrador, Lorena González-Costello, José Niubo Bosch, Jordi Calatayud Samper, Laura Maestro Benedicto, Alba Farrero Torres, Marta Blasco Peiró, Teresa Almenar Bonet, Luis Blázquez Bermejo, Zorba Garrido Bravo, Iris Gran Ipiña, Ferran Grande Trillo, Antonio Manito, Nicolas Moreno González, Gabriel Inflamació Apoptosi Trasplantament cardíac Inflammation Apoptosis Heart transplantation Primary graft dysfunction (PGD) remains a major cause of early morbidity and mortality after a heart transplant (HTx). Understanding the donor-related mechanisms involved may help improve organ selection and post-HTx outcomes. This study aimed to explore the association between the donor serum biomarkers of cell death and inflammation and the incidence of PGD and rejection in HTx recipients. We conducted a retrospective, multicenter observational study of brain-dead (DBD) heart donors and corresponding recipients between 2013 and 2019. Donor blood samples were analyzed for inflammatory cytokines, cell death-related proteins, and mitochondrial (mtDNA) and genomic DNA (gDNA). A total of 39 donor-recipient pairs were included. Sixteen recipients developed severe PGD, and five experienced >= 2R cellular rejection. Donors whose recipients developed PGD had significantly lower serum Caspase-3 levels compared to those without PGD (391.6 [101.8-1003.3] vs. 65.3 [40.2-163.3] pg/mL; p = 0.04). A trend toward lower mtDNA/gDNA ratio was also observed in the same group (10.5 [5.4-24.6] vs. 6.5 [3.3-10.7]; p = 0.067). Lower Caspase-3 levels in donor serum were significantly associated with the development of severe PGD in recipients. This may suggest that the sublethal activation of apoptotic pathways in the donor could play a protective role, potentially conditioning the graft to tolerate ischemic injury. MDPI https://hdl.handle.net/2445/224333
title Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
spellingShingle Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
Herrador, Lorena
Inflamació
Apoptosi
Trasplantament cardíac
Inflammation
Apoptosis
Heart transplantation
title_short Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
title_full Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
title_fullStr Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
title_full_unstemmed Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
title_sort Caspase-3 in Brain Death Donors Is Associated with Reduced Primary Graft Dysfunction After Heart Transplantation
author Herrador, Lorena
author_facet Herrador, Lorena
González-Costello, José
Niubo Bosch, Jordi
Calatayud Samper, Laura
Maestro Benedicto, Alba
Farrero Torres, Marta
Blasco Peiró, Teresa
Almenar Bonet, Luis
Blázquez Bermejo, Zorba
Garrido Bravo, Iris
Gran Ipiña, Ferran
Grande Trillo, Antonio
Manito, Nicolas
Moreno González, Gabriel
author_role author
author2 González-Costello, José
Niubo Bosch, Jordi
Calatayud Samper, Laura
Maestro Benedicto, Alba
Farrero Torres, Marta
Blasco Peiró, Teresa
Almenar Bonet, Luis
Blázquez Bermejo, Zorba
Garrido Bravo, Iris
Gran Ipiña, Ferran
Grande Trillo, Antonio
Manito, Nicolas
Moreno González, Gabriel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
topic Inflamació
Apoptosi
Trasplantament cardíac
Inflammation
Apoptosis
Heart transplantation
topic_facet Inflamació
Apoptosi
Trasplantament cardíac
Inflammation
Apoptosis
Heart transplantation
description Primary graft dysfunction (PGD) remains a major cause of early morbidity and mortality after a heart transplant (HTx). Understanding the donor-related mechanisms involved may help improve organ selection and post-HTx outcomes. This study aimed to explore the association between the donor serum biomarkers of cell death and inflammation and the incidence of PGD and rejection in HTx recipients. We conducted a retrospective, multicenter observational study of brain-dead (DBD) heart donors and corresponding recipients between 2013 and 2019. Donor blood samples were analyzed for inflammatory cytokines, cell death-related proteins, and mitochondrial (mtDNA) and genomic DNA (gDNA). A total of 39 donor-recipient pairs were included. Sixteen recipients developed severe PGD, and five experienced >= 2R cellular rejection. Donors whose recipients developed PGD had significantly lower serum Caspase-3 levels compared to those without PGD (391.6 [101.8-1003.3] vs. 65.3 [40.2-163.3] pg/mL; p = 0.04). A trend toward lower mtDNA/gDNA ratio was also observed in the same group (10.5 [5.4-24.6] vs. 6.5 [3.3-10.7]; p = 0.067). Lower Caspase-3 levels in donor serum were significantly associated with the development of severe PGD in recipients. This may suggest that the sublethal activation of apoptotic pathways in the donor could play a protective role, potentially conditioning the graft to tolerate ischemic injury.
publishDate 2025
format article
status_str publishedVersion
url https://hdl.handle.net/2445/224333
eu_rights_str_mv openAccess
publisher MDPI
institution Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
collection Recercat. Dipósit de la Recerca de Catalunya
reponame_str Recercat. Dipósit de la Recerca de Catalunya
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
_version_ 1878437438776410112
publishDateSort 2025
author_browse Almenar Bonet, Luis
Blasco Peiró, Teresa
Blázquez Bermejo, Zorba
Calatayud Samper, Laura
Farrero Torres, Marta
Garrido Bravo, Iris
González-Costello, José
Gran Ipiña, Ferran
Grande Trillo, Antonio
Herrador, Lorena
Maestro Benedicto, Alba
Manito, Nicolas
Moreno González, Gabriel
Niubo Bosch, Jordi
publisherStr MDPI
score 6,924472

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