Magnetically propelled chained nanocomposites for biologically relevant media exploration

Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical i...

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Autores: Ramos-Docampo, Miguel A, Hurtado, Pablo, Dávila-Ibáñez, Ana B, Piñeiro, Roberto, López Fanarraga, Mónica|||0000-0003-4754-311X, Salgueiriño, Verónica
Tipo de recurso: artículo
Fecha de publicación:2023
País:España
Institución:Universidad de Cantabria (UC)
Repositorio:UCrea Repositorio Abierto de la Universidad de Cantabria
Idioma:inglés
OAI Identifier:oai:repositorio.unican.es:10902/26552
Acceso en línea:https://hdl.handle.net/10902/26552
Access Level:acceso abierto
Palabra clave:Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
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spelling Magnetically propelled chained nanocomposites for biologically relevant media exploration Ramos-Docampo, Miguel A Hurtado, Pablo Dávila-Ibáñez, Ana B Piñeiro, Roberto López Fanarraga, Mónica|||0000-0003-4754-311X Salgueiriño, Verónica Magnetic swimmers Magnetophoretic mobility Viscosity Zebrafish yolk sac Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved. Acknowledgments: M. A. R.-D. acknowledges financial support from the Xunta de Galicia (Regional Government, Spain) under grant 2017-ED481A/322. P. H. is a recipient of a Predoctoral fellowship (IN606A-2018/019) from Axencia Galega de Innovación (GAIN, Xunta de Galicia). R. P. and A. B. D.-I. are supported by Roche-Chus Joint Unit (IN853B 2018/03) funded by GAIN, Consellería de Economía, Emprego e Industria, Xunta de Galicia. A. B. D.-I. acknowledges financial support from the Ministerio de Economía y Competitividad under Sara Borrell contract. M. L. F. acknowledge the financial support from the Spanish MINECO, Instituto de Salud Carlos III and the European Union FEDER funds under Projects ref. PI16/00496, PI19/00349, DTS19/00033 and the NanoBioApp Network (MINECO-17-MAT2016-81955-REDT). V. S. acknowledges the financial support from the Spanish Ministerio de Ciencia e Innovación under project PID2020-119242-I00 and from the European Union under project H2020-MSCA-RISE-2019 PEPSA-MATE (project number 872233). V. S. acknowledges for funding for open access charge: Universidade de Vigo/CISUG. Elsevier https://hdl.handle.net/10902/26552
title Magnetically propelled chained nanocomposites for biologically relevant media exploration
spellingShingle Magnetically propelled chained nanocomposites for biologically relevant media exploration
Ramos-Docampo, Miguel A
Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
title_short Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_full Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_fullStr Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_full_unstemmed Magnetically propelled chained nanocomposites for biologically relevant media exploration
title_sort Magnetically propelled chained nanocomposites for biologically relevant media exploration
author Ramos-Docampo, Miguel A
author_facet Ramos-Docampo, Miguel A
Hurtado, Pablo
Dávila-Ibáñez, Ana B
Piñeiro, Roberto
López Fanarraga, Mónica|||0000-0003-4754-311X
Salgueiriño, Verónica
author_role author
author2 Hurtado, Pablo
Dávila-Ibáñez, Ana B
Piñeiro, Roberto
López Fanarraga, Mónica|||0000-0003-4754-311X
Salgueiriño, Verónica
author2_role author
author
author
author
author
topic Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
topic_facet Magnetic swimmers
Magnetophoretic mobility
Viscosity
Zebrafish yolk sac
description Elongated nanostructures to be remotely and magnetically propelled in biologically relevant media, have gained attention as offering themselves as effective tools or carriers in theragnostics applications. However, the magnetic actuation associated remains challenging due to the lack of mechanical information in the media of interest, taking into account biophysical or biomedical purposes. In this study, we detail the magnetic actuation of magnetically propelled chained nanocomposites considering their dynamics, in which their velocity can be modulated in terms of the viscosity of the medium considered, given a magnetic field gradient. Simpler cases of distilled water, a water/glycerol mixture and a fluid made of cell extracts (imitating the cytosol of cells) of known viscosity are the basis experiments for the study of more complex media inside HeLa cells, murine NIH-3T3 fibroblasts and zebrafish larvae, offering the mechanical information required. The experimental results indicate that the magnetically propelled performance of the chained nanostructures can be precisely controlled in potentially changing scenarios, where drug and heat delivery, magnetic separation, or microfluidic technologies are demanded, using a magnetic field gradient and providing good estimations of the dynamical parameters involved.
publishDate 2023
format article
url https://hdl.handle.net/10902/26552
language eng
eu_rights_str_mv openAccess
publisher Elsevier
institution Universidad de Cantabria (UC)
collection UCrea Repositorio Abierto de la Universidad de Cantabria
reponame_str UCrea Repositorio Abierto de la Universidad de Cantabria
instname_str Universidad de Cantabria (UC)
_version_ 1878437762024079360
publishDateSort 2023
author_browse Dávila-Ibáñez, Ana B
Hurtado, Pablo
López Fanarraga, Mónica|||0000-0003-4754-311X
Piñeiro, Roberto
Ramos-Docampo, Miguel A
Salgueiriño, Verónica
publisherStr Elsevier
score 6.924472

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