Cow’s Milk‑related Symptom Score (CoMiSS) values in presumed healthy European infants aged 6–12 months: a cross‑sectional study

The Cow’s Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating cow’s milk-related symptoms. Previous studies have focused on providing CoMiSS values for healthy and symptomatic infants aged 0–6 months. However, there is a notable gap in the literature concerning CoMiSS values for...

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Bibliographic Details
Authors: Jankiewicz, Mateusz, Ahmed, Fatme, Bajerova, Katerina, Carvajal Roca, Eva, Dupont, Christophe, Huysentruyt, Koen, Kuitunen, Mikael, Meyer, Rosan, Pancheva, Rouzha, Ribes Koninckx, Carmen, Salvatore, Silvia, Shamir, Raanan, Staiano, Annamaria, Vandenplas, Yvan, Szajewska, Hania
Format: article
Publication Date:2024
Country:España
Institution:Universidad Católica de Valencia San Vicente Mártir
Repository:RIUCV. Repositorio de la Universidad Católica de Valencia San Vicente Mártir
Language:English
OAI Identifier:oai:riucv.ucv.es:20.500.12466/4410
Online Access:http://hdl.handle.net/20.500.12466/4410
Access Level:Open access
Keyword:Cow’s milk allergy
Awareness
Tool
Infant feeding
CoMiSS
3201.10 Pediatría
Description
Summary:The Cow’s Milk-related Symptom Score (CoMiSS) is an awareness tool for evaluating cow’s milk-related symptoms. Previous studies have focused on providing CoMiSS values for healthy and symptomatic infants aged 0–6 months. However, there is a notable gap in the literature concerning CoMiSS values for infants older than 6 months. This cross-sectional study aimed to determine CoMiSS values in presumed healthy infants who have completed 6 months and are up to 12 months old, hereafter referred to as 6 to 12 months old. Physicians from six European countries prospectively determined CoMiSS values in infants attending well-child clinics. Exclusion criteria included preterm delivery, acute or chronic disease, and the consumption of a therapeutic formula, dietary supplements (except vitamins), or medication. The following information was collected: gestational age, gender, age, type of feed (breast milk or infant formula), and complementary feeding. Descriptive statistics were summarized with mean and standard deviation for normally distributed continuous variables, median and IQR for non-normally distributed variables, and differences in CoMiSS values were analyzed with appropriate tests. Data from 609 infants were obtained. The overall median (Q1–Q3) CoMiSS values were 3 (1–5). Significant differences were found across age groups (p < 0.001), but not across groups based on gender (p = 0.551) or feeding type (p = 0.880).