Human type I IFN deficiency does not impair B cell response to SARS-CoV-2 mRNA vaccination

Intact B cell responses to SARS-CoV-2 mRNA vaccines in patients with genetic or acquired type I IFN deficiencies suggest that type I IFNs induced by mRNA vaccines are not required for vaccine efficacy. Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening CO...

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Detalles Bibliográficos
Autores: Sokal, Aurélien, Bastard, Paul, Chappert, Pascal, Barba Spaeth, Giovanna, Fourati, Slim, Vanderberghe, Alexis, Lagouge Roussey, Pauline, Meyts, Isabelle, Gervais, Adrian, Bouvier Alias, Magali, Azzaoui, Imane, Fernández, Ignacio, La Selle, Andréa de, Zhang, Qian, Bizien, Lucy, Pellier, Isabelle, Linglart, Agnès, Rothenbuhler, Anya, Marcoux, Estelle, Anxionnat, Raphael, Cheikh, Nathalie, Léger, Juliane, Amador Borrero, Blanca, Fouyssac, Fanny, Menut, Vanessa, Goffard, Jean Christophe, Storey, Caroline, Demily, Caroline, Mallebranche, Coralie, Troya, Jesus, Pujol, Aurora, Zins, Marie, Tiberghien, Pierre, Gray, Paul E., Mcnaughton, Peter, Sullivan, Anna, Peake, Jane, Levy, Romain, Languille, Laetitia, Rodiguez Gallego, Carlos, Boisson, Bertrand, Gallien, Sébastien, Neven, Bénédicte, Michel, Marc, Godeau, Bertrand, Abel, Laurent, Rey, Felix A., Weill, Jean Claude, Reynaud, Claude Agnès, Tangye, Stuart G., Casanova, Jean Laurent, Mahévas, Matthieu
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/224137
Acceso en línea:https://hdl.handle.net/2445/224137
Access Level:acceso abierto
Palabra clave:Immunoregulació
Betacoronavirus
Antígens
Immunoregulation
Antigens
Descripción
Sumario:Intact B cell responses to SARS-CoV-2 mRNA vaccines in patients with genetic or acquired type I IFN deficiencies suggest that type I IFNs induced by mRNA vaccines are not required for vaccine efficacy. Inborn and acquired deficits of type I interferon (IFN) immunity predispose to life-threatening COVID-19 pneumonia. We longitudinally profiled the B cell response to mRNA vaccination in SARS-CoV-2 naive patients with inherited TLR7, IRF7, or IFNAR1 deficiency, as well as young patients with autoantibodies neutralizing type I IFNs due to autoimmune polyendocrine syndrome type-1 (APS-1) and older individuals with age-associated autoantibodies to type I IFNs. The receptor-binding domain spike protein (RBD)-specific memory B cell response in all patients was quantitatively and qualitatively similar to healthy donors. Sustained germinal center responses led to accumulation of somatic hypermutations in immunoglobulin heavy chain genes. The amplitude and duration of, and viral neutralization by, RBD-specific IgG serological response were also largely unaffected by TLR7, IRF7, or IFNAR1 deficiencies up to 7 mo after vaccination in all patients. These results suggest that induction of type I IFN is not required for efficient generation of a humoral response against SARS-CoV-2 by mRNA vaccines.

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