Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa
Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestin...
| Autores: | , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2009 |
| País: | España |
| Institución: | Universidad de Valladolid |
| Repositorio: | UVaDOC. Repositorio Documental de la Universidad de Valladolid |
| OAI Identifier: | oai:uvadoc.uva.es:10324/4436 |
| Acceso en línea: | https://doi.org/10.1136/gut.2008.167296 http://uvadoc.uva.es/handle/10324/4436 |
| Access Level: | acceso abierto |
| Palabra clave: | Enfermedad celíaca Gliadina Intestinos - Enfermedades |
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oai:uvadoc.uva.es:10324/4436 |
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ES |
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España |
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Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa Bernardo Ordiz, David Garrote Adrados, José Antonio Nadal, I. León, Alberto José Calvo Romero, María Del Carmen Fernández Salazar, Luis Ignacio Blanco Quiros, Alfredo Sanz, Y. Arranz Sanz, Eduardo Enfermedad celíaca Gliadina Intestinos - Enfermedades Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD. BMJ https://doi.org/10.1136/gut.2008.167296 http://uvadoc.uva.es/handle/10324/4436 |
| title |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa |
| spellingShingle |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa Bernardo Ordiz, David Enfermedad celíaca Gliadina Intestinos - Enfermedades |
| title_short |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa |
| title_full |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa |
| title_fullStr |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa |
| title_full_unstemmed |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa |
| title_sort |
Is it true coeliacs do not digest gliadin? Degradation pattern of gliadin in coeliac disease small intestinal mucosa |
| author |
Bernardo Ordiz, David |
| author_facet |
Bernardo Ordiz, David Garrote Adrados, José Antonio Nadal, I. León, Alberto José Calvo Romero, María Del Carmen Fernández Salazar, Luis Ignacio Blanco Quiros, Alfredo Sanz, Y. Arranz Sanz, Eduardo |
| author_role |
author |
| author2 |
Garrote Adrados, José Antonio Nadal, I. León, Alberto José Calvo Romero, María Del Carmen Fernández Salazar, Luis Ignacio Blanco Quiros, Alfredo Sanz, Y. Arranz Sanz, Eduardo |
| author2_role |
author author author author author author author author |
| topic |
Enfermedad celíaca Gliadina Intestinos - Enfermedades |
| topic_facet |
Enfermedad celíaca Gliadina Intestinos - Enfermedades |
| description |
Prolyl-endopeptidase supplementation has been proposed to favour gliadin degradation as an alternative treatment for coeliac disease (CD), although the real usefulness of this therapy in vivo is still under discussion. 1 However, our data point to alternative treatments aiming to modify the intestinal microbiota in patients with CD by the use of probiotics and/or prebiotics. We propose that the induction of gliadin proteolysis in the human gut might not be the solution but the origin of CD. |
| publishDate |
2009 |
| format |
article |
| status_str |
acceptedVersion |
| url |
https://doi.org/10.1136/gut.2008.167296 http://uvadoc.uva.es/handle/10324/4436 |
| eu_rights_str_mv |
openAccess |
| publisher |
BMJ |
| institution |
Universidad de Valladolid |
| collection |
UVaDOC. Repositorio Documental de la Universidad de Valladolid |
| reponame_str |
UVaDOC. Repositorio Documental de la Universidad de Valladolid |
| instname_str |
Universidad de Valladolid |
| _version_ |
1878438750571200512 |
| publishDateSort |
2009 |
| author_browse |
Arranz Sanz, Eduardo Bernardo Ordiz, David Blanco Quiros, Alfredo Calvo Romero, María Del Carmen Fernández Salazar, Luis Ignacio Garrote Adrados, José Antonio León, Alberto José Nadal, I. Sanz, Y. |
| publisherStr |
BMJ |
| score |
6,9303427 |