Robust and fault-tolerant strategies for controlling blood glucose in patients with type 1 diabetes
Type 1 diabetes is a serious disease that must be monitored and controlled artificially by supplying exogenous insulin to the body. The artificial pancreas (AP) is a closed-loop system that resulted from integrating an insulin pump with a CGM and uses a control algorithm to automate insulin infusion...
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| Formato: | tesis doctoral |
| Estado: | Versión publicada |
| Fecha de publicación: | 2020 |
| País: | España |
| Recursos: | CBUC, CESCA |
| Repositorio: | TDR. Tesis Doctorales en Red |
| OAI Identifier: | oai:www.tdx.cat:10803/670998 |
| Acesso em linha: | http://hdl.handle.net/10803/670998 |
| Access Level: | acceso abierto |
| Palavra-chave: | Artificial pancreas Pàncrees artificial Páncreas artificial Patient in the loop Type 1 diabetes Diabetis tipus 1 Diabetes tipo 1 Fault detection Detecció d'errors Detección de errores Physical activity Activitat física Actividad física Blood glucose Glucèmia Glucemia Postprandial control Control postprandial 616.4 621.3 68 |
| Resumo: | Type 1 diabetes is a serious disease that must be monitored and controlled artificially by supplying exogenous insulin to the body. The artificial pancreas (AP) is a closed-loop system that resulted from integrating an insulin pump with a CGM and uses a control algorithm to automate insulin infusion. In this work, a novel tuning system and a multivariable control approach are presented for an AP system aimed to be robust against patient variability, meals and exercise. To enhance safety, fault detection 2/2 strategies are also developed as an integral part of the system. The approaches have been extensively validated in simulation and in an inpatient clinical trial |
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