Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets

Migraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and...

Full description

Bibliographic Details
Author: Domínguez Vivero, Clara
Format: doctoral thesis
Publication Date:2021
Country:España
Institution:Universidad de Santiago de Compostela (USC)
Repository:Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
Language:English
OAI Identifier:oai:minerva.usc.gal:10347/26289
Online Access:http://hdl.handle.net/10347/26289
Access Level:Open access
Keyword:Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
id ES_a67af4b168ad88ea7fbdd2bb307e4fb2
oai_identifier_str oai:minerva.usc.gal:10347/26289
network_acronym_str ES
network_name_str España
spelling Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets Domínguez Vivero, Clara Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología Migraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and TLR4) is increased in chronic migraine (CM) patients, and if TLR4 is involved in the vascular response to CSD. With this aim, we designed a clinical cross-sectional study measuring peripheral blood expression of TLR2 and TLR4 and a experimental study based on an animal model of cortical spreading depolarization (CSD). CM patients showed increased expression of TLR4 and TLR2 in peripheral blood. TLR4 KO mice had a different response to CSD stimulation that was reproduced after pharmacological blockade of TLR4. Our results suggest that TLR2 and TLR4 may have a role in migraine pathophysiology, providing a potential novel strategy for treatment. http://hdl.handle.net/10347/26289
title Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
spellingShingle Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
Domínguez Vivero, Clara
Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
title_short Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_full Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_fullStr Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_full_unstemmed Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
title_sort Changes in innate immunity in chronic migraine. Role of Toll-like receptors 2 and 4 as key players in migraine chronification and potential therapeutic targets
author Domínguez Vivero, Clara
author_facet Domínguez Vivero, Clara
author_role author
topic Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
topic_facet Materias::Investigación::32 Ciencias médicas::3205 Medicina interna::320507 Neurología
Materias::Investigación::32 Ciencias médicas::3207 Patología::320711 Neuropatología
description Migraine is a complex disorder that involves several physiopathological mechanisms. Toll-like receptors (TLRs) are involved in neuroinflammation, but their role in migraine is not completely understood. This translational study investigates whether expression of Toll-like receptors 2 and 4 (TLR2 and TLR4) is increased in chronic migraine (CM) patients, and if TLR4 is involved in the vascular response to CSD. With this aim, we designed a clinical cross-sectional study measuring peripheral blood expression of TLR2 and TLR4 and a experimental study based on an animal model of cortical spreading depolarization (CSD). CM patients showed increased expression of TLR4 and TLR2 in peripheral blood. TLR4 KO mice had a different response to CSD stimulation that was reproduced after pharmacological blockade of TLR4. Our results suggest that TLR2 and TLR4 may have a role in migraine pathophysiology, providing a potential novel strategy for treatment.
publishDate 2021
format doctoralThesis
url http://hdl.handle.net/10347/26289
language eng
eu_rights_str_mv openAccess
institution Universidad de Santiago de Compostela (USC)
collection Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
reponame_str Minerva. Repositorio Institucional de la Universidad de Santiago de Compostela
instname_str Universidad de Santiago de Compostela (USC)
_version_ 1878438907158200321
publishDateSort 2021
author_browse Domínguez Vivero, Clara
score 6.9303427

Similar Items