Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses
Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, w...
| Autores: | , , |
|---|---|
| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2015 |
| País: | España |
| Institución: | Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| Repositorio: | Recercat. Dipósit de la Recerca de Catalunya |
| OAI Identifier: | oai:recercat.cat:2445/121073 |
| Acceso en línea: | https://hdl.handle.net/2445/121073 |
| Access Level: | acceso abierto |
| Palabra clave: | Diferenciació cel·lular Morfologia (Biologia) Cell diferentiation Morphology (Biology) |
| id |
ES_a68e2cfa3cbc9b968d56d4adb42abda7 |
|---|---|
| oai_identifier_str |
oai:recercat.cat:2445/121073 |
| network_acronym_str |
ES |
| network_name_str |
España |
| spelling |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses Lagunas, Anna Martínez Fraiz, Elena Samitier i Martí, Josep Diferenciació cel·lular Morfologia (Biologia) Cell diferentiation Morphology (Biology) Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, we review some of the most recent examples in which gradients have been used to evaluate the effect of a varying ligand concentration in cell adhesion, morphology, growth, and differentiation of cells, including some of our recent findings. They show the importance of the organization of ligands at the nanoscale, which is highlighted by abrupt changes in cell behavior at critical concentration thresholds. Frontiers Media https://hdl.handle.net/2445/121073 |
| title |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses |
| spellingShingle |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses Lagunas, Anna Diferenciació cel·lular Morfologia (Biologia) Cell diferentiation Morphology (Biology) |
| title_short |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses |
| title_full |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses |
| title_fullStr |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses |
| title_full_unstemmed |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses |
| title_sort |
Surface-Bound Molecular Gradients for the High-Throughput Screening of Cell Responses |
| author |
Lagunas, Anna |
| author_facet |
Lagunas, Anna Martínez Fraiz, Elena Samitier i Martí, Josep |
| author_role |
author |
| author2 |
Martínez Fraiz, Elena Samitier i Martí, Josep |
| author2_role |
author author |
| topic |
Diferenciació cel·lular Morfologia (Biologia) Cell diferentiation Morphology (Biology) |
| topic_facet |
Diferenciació cel·lular Morfologia (Biologia) Cell diferentiation Morphology (Biology) |
| description |
Chemical gradient surfaces are described as surfaces with a gradually varying composition along their length. Continuous chemical gradients have recently been proposed as an alternative to discrete microarrays for the high-throughput screening of the effects of ligand concentration in cells. Here, we review some of the most recent examples in which gradients have been used to evaluate the effect of a varying ligand concentration in cell adhesion, morphology, growth, and differentiation of cells, including some of our recent findings. They show the importance of the organization of ligands at the nanoscale, which is highlighted by abrupt changes in cell behavior at critical concentration thresholds. |
| publishDate |
2015 |
| format |
article |
| status_str |
publishedVersion |
| url |
https://hdl.handle.net/2445/121073 |
| eu_rights_str_mv |
openAccess |
| publisher |
Frontiers Media |
| institution |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| collection |
Recercat. Dipósit de la Recerca de Catalunya |
| reponame_str |
Recercat. Dipósit de la Recerca de Catalunya |
| instname_str |
Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) |
| _version_ |
1878438913118306304 |
| publishDateSort |
2015 |
| author_browse |
Lagunas, Anna Martínez Fraiz, Elena Samitier i Martí, Josep |
| publisherStr |
Frontiers Media |
| score |
6,9303427 |