Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview
Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and r...
| Autores: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2022 |
| País: | España |
| Institución: | Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| Repositorio: | r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| OAI Identifier: | oai:iibsantpau.fundanetsuite.com:p5850 |
| Acceso en línea: | https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850 https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal- |
| Access Level: | acceso abierto |
| Palabra clave: | Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization |
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Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview Delaby, C Teunissen, CE Blennow, K Alcolea, D Arisi, I Amar, EB Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Boada, M Bousiges, O Chapman, MD DeMarco, ML D'Onofrio, M Dumurgier, J Dufour-Rainfray, D Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paquet, C Paoletti, FP Parnetti, L Perret-Liaudet, A Peoc'h, K Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schraen, S Schott, JM Shaw, LM Suarez-Calvet, M Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H Lehmann, S Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD. WILEY https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850 https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal- |
| title |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview |
| spellingShingle |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview Delaby, C Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization |
| title_short |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview |
| title_full |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview |
| title_fullStr |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview |
| title_full_unstemmed |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview |
| title_sort |
Clinical reporting following the quantification of cerebrospinal fluid biomarkers in Alzheimer's disease: An international overview |
| author |
Delaby, C |
| author_facet |
Delaby, C Teunissen, CE Blennow, K Alcolea, D Arisi, I Amar, EB Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Boada, M Bousiges, O Chapman, MD DeMarco, ML D'Onofrio, M Dumurgier, J Dufour-Rainfray, D Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paquet, C Paoletti, FP Parnetti, L Perret-Liaudet, A Peoc'h, K Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schraen, S Schott, JM Shaw, LM Suarez-Calvet, M Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H Lehmann, S |
| author_role |
author |
| author2 |
Teunissen, CE Blennow, K Alcolea, D Arisi, I Amar, EB Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Boada, M Bousiges, O Chapman, MD DeMarco, ML D'Onofrio, M Dumurgier, J Dufour-Rainfray, D Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paquet, C Paoletti, FP Parnetti, L Perret-Liaudet, A Peoc'h, K Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schraen, S Schott, JM Shaw, LM Suarez-Calvet, M Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H Lehmann, S |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author |
| topic |
Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization |
| topic_facet |
Alzheimer's disease cerebrospinal fluid biomarkers clinical report consensus approach harmonization |
| description |
Introduction: The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis of Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting of resultsmay differ, which can lead tomisunderstandings and raises questions about the commutability of tests. Methods: We obtained a description of (pre-)analytical protocols and sample reports from 40 centers worldwide. A consensus approach allowed us to propose harmonized comments corresponding to the different CSF biomarker profiles observed in patients. Results: The (pre-)analytical procedures were similar between centers. There was considerable heterogeneity in cutoff definitions and report comments. We therefore identified and selected by consensus the most accurate and informative comments regarding the interpretation of CSF biomarkers in the context of AD diagnosis. Discussion: This is the first time that harmonized reports are proposed across worldwide specialized laboratories involved in the biochemical diagnosis of AD. |
| publishDate |
2022 |
| format |
article |
| status_str |
publishedVersion |
| url |
https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=5850 https://researchportal.vub.be/en/publications/clinical-reporting-following-the-quantification-of-cerebrospinal- |
| eu_rights_str_mv |
openAccess |
| publisher |
WILEY |
| institution |
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| collection |
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| reponame_str |
r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau |
| instname_str |
Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau) |
| _version_ |
1878439045428674560 |
| publishDateSort |
2022 |
| author_browse |
Alcolea, D Amar, EB Arisi, I Beaume, A Bedel, A Bellomo, G Bigot-Corbel, E Bjerke, M Blanc-Quintin, MC Blennow, K Boada, M Bousiges, O Chapman, MD D'Onofrio, M DeMarco, ML Delaby, C Dufour-Rainfray, D Dumurgier, J Engelborghs, S Esselmann, H Fogli, A Gabelle, A Galloni, E Gondolf, C Grandhomme, F Grau-Rivera, O Hart, M Ikeuchi, T Jeromin, A Kasuga, K Keshavan, A Khalil, M Kortvelyessy, P Kulczynska-Przybik, A Laplanche, JL Lehmann, S Lewczuk, P Li, QX Lleo, A Malaplate, C Marquie, M Masters, CL Mroczko, B Nogueira, L Orellana, A Otto, M Oudart, JB Paoletti, FP Paquet, C Parnetti, L Peoc'h, K Perret-Liaudet, A Poesen, K Puig-Pijoan, A Quadrio, I Quillard-Muraine, M Rucheton, B Schott, JM Schraen, S Shaw, LM Suarez-Calvet, M Teunissen, CE Tsolaki, M Tumani, H Udeh-Momoh, CT Vaudran, L Verbeek, MM Verde, F Vermunt, L Vogelgsang, J Wiltfang, J Zetterberg, H |
| publisherStr |
WILEY |
| score |
6,9303427 |