Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh

Excess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk...

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Autores: Florensa Cazorla, Dídac, Mateo Fornés, Jordi, Solsona Tehàs, Francesc, Galván, Leonardo, Mesas, Miquel, Piñol, Ramon, Espinosa-Leal, Leonardo, Godoy i García, Pere
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10459.1/463146
Acceso en línea:https://doi.org/10.3390/ijerph20054104
https://hdl.handle.net/10459.1/463146
Access Level:acceso abierto
Palabra clave:Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
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network_name_str España
spelling Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh Florensa Cazorla, Dídac Mateo Fornés, Jordi Solsona Tehàs, Francesc Galván, Leonardo Mesas, Miquel Piñol, Ramon Espinosa-Leal, Leonardo Godoy i García, Pere Colorectal cancer Aspirin use Excess weight Smoking Risky drinking Excess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk of developing CRC. We performed a retrospective cohort study of CRC risk factors and aspirin use in persons aged >50 years in Lleida province. The participants were inhabitants with some medication prescribed between 2007 and 2016 that were linked to the Population-Based Cancer Registry to detect CRC diagnosed between 2012 and 2016. Risk factors and aspirin use were studied using the adjusted HR (aHR) with 95% confidence intervals (CI) using a Cox proportional hazard model. We included 154,715 inhabitants of Lleida (Spain) aged >50 years. Of patients with CRC, 62% were male (HR = 1.8; 95% CI: 1.6–2.2), 39.5% were overweight (HR = 2.8; 95% CI: 2.3–3.4) and 47.3% were obese (HR = 3.0; 95% CI: 2.6–3.6). Cox regression showed an association between aspirin and CRC (aHR = 0.7; 95% CI: 0.6–0.8), confirming a protective effect against CRC and an association between the risk of CRC and excess weight (aHR = 1.4; 95% CI: 1.2–1.7), smoking (aHR = 1.4; 95% CI: 1.3–1.7) and risky drinking (aHR = 1.6; 95% CI: 1.2–2.0). Our results show that aspirin use decreased the risk of CRC and corroborate the relationship between overweight, smoking and risky drinking and the risk of CRC. his work was supported by contract 2019-DI-43 of the Industrial Doctorate Program of the Government of Catalonia. Project PID2020-113614RB-C22 was funded by the Spanish Ministry of Science and Innovation. Some authors are members of the 2014-SGR163 research group, funded by the Generalitat de Catalunya. MDPI https://doi.org/10.3390/ijerph20054104 https://hdl.handle.net/10459.1/463146
title Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
spellingShingle Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
Florensa Cazorla, Dídac
Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
title_short Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_full Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_fullStr Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_full_unstemmed Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
title_sort Acetylsalicylic Acid Effect in Colorectal Cancer Taking into Account the Role of Tobacco, Alcohol and Excess Weigh
author Florensa Cazorla, Dídac
author_facet Florensa Cazorla, Dídac
Mateo Fornés, Jordi
Solsona Tehàs, Francesc
Galván, Leonardo
Mesas, Miquel
Piñol, Ramon
Espinosa-Leal, Leonardo
Godoy i García, Pere
author_role author
author2 Mateo Fornés, Jordi
Solsona Tehàs, Francesc
Galván, Leonardo
Mesas, Miquel
Piñol, Ramon
Espinosa-Leal, Leonardo
Godoy i García, Pere
author2_role author
author
author
author
author
author
author
topic Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
topic_facet Colorectal cancer
Aspirin use
Excess weight
Smoking
Risky drinking
description Excess weight, smoking and risky drinking are preventable risk factors for colorectal cancer (CRC). However, several studies have reported a protective association between aspirin and the risk of CRC. This article looks deeper into the relationships between risk factors and aspirin use with the risk of developing CRC. We performed a retrospective cohort study of CRC risk factors and aspirin use in persons aged >50 years in Lleida province. The participants were inhabitants with some medication prescribed between 2007 and 2016 that were linked to the Population-Based Cancer Registry to detect CRC diagnosed between 2012 and 2016. Risk factors and aspirin use were studied using the adjusted HR (aHR) with 95% confidence intervals (CI) using a Cox proportional hazard model. We included 154,715 inhabitants of Lleida (Spain) aged >50 years. Of patients with CRC, 62% were male (HR = 1.8; 95% CI: 1.6–2.2), 39.5% were overweight (HR = 2.8; 95% CI: 2.3–3.4) and 47.3% were obese (HR = 3.0; 95% CI: 2.6–3.6). Cox regression showed an association between aspirin and CRC (aHR = 0.7; 95% CI: 0.6–0.8), confirming a protective effect against CRC and an association between the risk of CRC and excess weight (aHR = 1.4; 95% CI: 1.2–1.7), smoking (aHR = 1.4; 95% CI: 1.3–1.7) and risky drinking (aHR = 1.6; 95% CI: 1.2–2.0). Our results show that aspirin use decreased the risk of CRC and corroborate the relationship between overweight, smoking and risky drinking and the risk of CRC.
publishDate 2023
format article
status_str publishedVersion
url https://doi.org/10.3390/ijerph20054104
https://hdl.handle.net/10459.1/463146
eu_rights_str_mv openAccess
publisher MDPI
institution Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
collection Recercat. Dipósit de la Recerca de Catalunya
reponame_str Recercat. Dipósit de la Recerca de Catalunya
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
_version_ 1878439341796098048
publishDateSort 2023
author_browse Espinosa-Leal, Leonardo
Florensa Cazorla, Dídac
Galván, Leonardo
Godoy i García, Pere
Mateo Fornés, Jordi
Mesas, Miquel
Piñol, Ramon
Solsona Tehàs, Francesc
publisherStr MDPI
score 6,924472

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