Histological response to radiotherapy is an early event in myxoid liposarcoma

Myxoid liposarcoma; Personalized medicine; Radiotherapy

Detalles Bibliográficos
Autores: Lam, Suk Wai, Silva, Tulio M., Traast-Kooistra, Jolanda, Briaire de Bruijn, Inge H., van den Akker, Brendy, Bakker, Pauline A. C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:11351/10664
Acceso en línea:https://hdl.handle.net/11351/10664
http://hdl.handle.net/11351/10664
Access Level:acceso abierto
Palabra clave:Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
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spelling Histological response to radiotherapy is an early event in myxoid liposarcoma Lam, Suk Wai Silva, Tulio M. Traast-Kooistra, Jolanda Briaire de Bruijn, Inge H. van den Akker, Brendy Bakker, Pauline A. C. Teixit adipós - Càncer - Radioteràpia Apoptosi DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis Myxoid liposarcoma; Personalized medicine; Radiotherapy Liposarcoma mixoide; Medicina personalizada; Radioterapia Liposarcoma mixoide; Medicina personalitzada; Radioteràpia Compared to other sarcomas, myxoid liposarcoma (MLS) is exceptionally sensitive to radiation therapy, but the underlying mechanism remains unknown. The objective was to assess the tissue-based changes in MLS during and after neoadjuvant radiotherapy in 26 patients of the DOREMY trial. Morphological assessment was performed on biopsies pre-treatment, after 8 fractions, 16 factions, and after surgical resection and included percentage of viable tumor cells, hyalinization, necrosis, and fatty maturation. Furthermore, immunohistochemistry was performed for apoptosis (cleaved caspase-3), anti-apoptosis (Bcl-2), activity of mTOR signaling (phospho-S6), hypoxia (CAIX), proliferation (Ki67), inflammation (CD45 and CD68), and microvessel density (CD34 Chalkley count). A pronounced reduction in vital tumor cells was observed early with a drop to 32.5% (median) tumor cells (IQR 10–93.8%) after 8 fractions. This decreased further to 10% (IQR 5–30%) after 16 fractions and 7.5% (IQR 5–15%) in the surgical specimen. All but one patient had an excellent response with < 50% remaining tumor cells. Inversely, treatment response was mainly observed as hyalinization and less often as fatty maturation. Additionally, a decrease of inflammatory cells was noticed especially during the first eight fractions. Microvessel density remained stable over time. Immunohistochemical markers for apoptosis, anti-apoptosis, activity of mTOR signaling, proliferation, and hypoxia did not show any marked changes within the remaining tumor cells during and after radiotherapy. As a modest dose of neoadjuvant radiotherapy induces profound tissue changes in MLS, mainly during the first 8 fractions, current findings might suggest that in a carefully selected patient population further deintensification of radiotherapy might be explored. Springer https://hdl.handle.net/11351/10664 http://hdl.handle.net/11351/10664
title Histological response to radiotherapy is an early event in myxoid liposarcoma
spellingShingle Histological response to radiotherapy is an early event in myxoid liposarcoma
Lam, Suk Wai
Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
title_short Histological response to radiotherapy is an early event in myxoid liposarcoma
title_full Histological response to radiotherapy is an early event in myxoid liposarcoma
title_fullStr Histological response to radiotherapy is an early event in myxoid liposarcoma
title_full_unstemmed Histological response to radiotherapy is an early event in myxoid liposarcoma
title_sort Histological response to radiotherapy is an early event in myxoid liposarcoma
author Lam, Suk Wai
author_facet Lam, Suk Wai
Silva, Tulio M.
Traast-Kooistra, Jolanda
Briaire de Bruijn, Inge H.
van den Akker, Brendy
Bakker, Pauline A. C.
author_role author
author2 Silva, Tulio M.
Traast-Kooistra, Jolanda
Briaire de Bruijn, Inge H.
van den Akker, Brendy
Bakker, Pauline A. C.
author2_role author
author
author
author
author
topic Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
topic_facet Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
description Myxoid liposarcoma; Personalized medicine; Radiotherapy
publishDate 2023
format article
status_str publishedVersion
url https://hdl.handle.net/11351/10664
http://hdl.handle.net/11351/10664
eu_rights_str_mv openAccess
publisher Springer
institution Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
collection Recercat. Dipósit de la Recerca de Catalunya
reponame_str Recercat. Dipósit de la Recerca de Catalunya
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
_version_ 1878439341959675904
publishDateSort 2023
author_browse Bakker, Pauline A. C.
Briaire de Bruijn, Inge H.
Lam, Suk Wai
Silva, Tulio M.
Traast-Kooistra, Jolanda
van den Akker, Brendy
publisherStr Springer
score 6.924472

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