Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans

Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United States

Detalles Bibliográficos
Autores: González Manzano, Susana, Ayuda Durán, María Begoña, Martín Sanz, Roberto, Garzón García, Lidia, Santos Buelga, Celestino, González Paramás, Ana María
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/162317
Acceso en línea:http://hdl.handle.net/10366/162317
Access Level:acceso embargado
Palabra clave:Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
enfermedad de Alzheimer
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spelling Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans González Manzano, Susana Ayuda Durán, María Begoña Martín Sanz, Roberto Garzón García, Lidia Santos Buelga, Celestino González Paramás, Ana María Alzheimer’s disease Caenorhabditis elegans grape seed polyphenol amyloid-β neuroprotection proteostasis Alzheimer Disease enfermedad de Alzheimer Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United States Alzheimer’s disease (AD), a major neurodegenerative disorder, is characterized by the progressive accumulation of amyloid-β (Aβ) plaques, leading to cognitive decline. Despite the existing treatments, their limited efficacy highlights the urgent need for novel therapeutic strategies. The present study investigates the neuroprotective effects of a grape seed polyphenol extract (GSPE) on transgenic Caenorhabditis elegans models specifically expressing human Aβ proteins. The obtained results show that GSPE not only significantly attenuates Aβ-induced paralysis but also extends the lifespan and improves sensory responses in these models, suggesting improved neural function and overall health. Additionally, GSPE treatment reduces proteasomal activity, which could lead to a reduction in the accumulation of misfolded proteins. It also modulates the expression of key genes involved in autophagy and proteostasis, thereby enhancing cellular mechanisms to manage protein aggregation and combat oxidative stress. On the whole, these findings support the potential of grape seed procyanidins (the main components in the extract) to be used as an effective dietary approach to mitigate Alzheimer’s disease pathology through the modulation of critical neuroprotective pathways. https://www.mdpi.com/2304-8158/13/23/3865 http://hdl.handle.net/10366/162317
title Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
spellingShingle Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
González Manzano, Susana
Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
enfermedad de Alzheimer
title_short Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_full Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_fullStr Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_full_unstemmed Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
title_sort Exploring the neuroprotective effects of grape seed procyanidins on Amyloid-β-Induced toxicity in Caenorhabditis elegans
author González Manzano, Susana
author_facet González Manzano, Susana
Ayuda Durán, María Begoña
Martín Sanz, Roberto
Garzón García, Lidia
Santos Buelga, Celestino
González Paramás, Ana María
author_role author
author2 Ayuda Durán, María Begoña
Martín Sanz, Roberto
Garzón García, Lidia
Santos Buelga, Celestino
González Paramás, Ana María
author2_role author
author
author
author
author
topic Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
enfermedad de Alzheimer
topic_facet Alzheimer’s disease
Caenorhabditis elegans
grape seed polyphenol
amyloid-β
neuroprotection
proteostasis
Alzheimer Disease
enfermedad de Alzheimer
description Some strains were provided by the CGC, which is funded by the NIH Office of Research Infrastructure Programs (P40 OD010440). Financiadores Consejería de Educación CyL SA106P24 National Institutes of Health United States P40 OD010440 National Institutes of Health United States
publishDate 2024
format article
status_str publishedVersion
url http://hdl.handle.net/10366/162317
eu_rights_str_mv embargoedAccess
publisher https://www.mdpi.com/2304-8158/13/23/3865
institution Universidad de Salamanca (USAL)
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname_str Universidad de Salamanca (USAL)
_version_ 1878439551898222592
publishDateSort 2024
author_browse Ayuda Durán, María Begoña
Garzón García, Lidia
González Manzano, Susana
González Paramás, Ana María
Martín Sanz, Roberto
Santos Buelga, Celestino
publisherStr https://www.mdpi.com/2304-8158/13/23/3865
score 6,9303427

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