Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France
14 páginas, 3 figuras, 1 tabla
| Autores: | , , , , , , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Consejo Superior de Investigaciones Científicas (CSIC) |
| Repositorio: | DIGITAL.CSIC. Repositorio Institucional del CSIC |
| OAI Identifier: | oai:digital.csic.es:10261/284037 |
| Acceso en línea: | http://hdl.handle.net/10261/284037 |
| Access Level: | acceso abierto |
| Palabra clave: | Tuberculosis Outbreak Beijing Cross-border WGS Strain-specific PCR |
| id |
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| oai_identifier_str |
oai:digital.csic.es:10261/284037 |
| network_acronym_str |
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| network_name_str |
España |
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Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France Genestet, Charlotte Perdigão, João Herranz, Marta Maus, Sandra R. Pérez Lago, Laura Berland, Jean-Luc Chiner-Oms, Álvaro Comas, Iñaki Muñoz, Patricia Portugal, Isabel Dumitrescu, Oana García de Viedma, Darío Tuberculosis Outbreak Beijing Cross-border WGS Strain-specific PCR 14 páginas, 3 figuras, 1 tabla Advanced epidemiological surveillance supported on genomic epidemiology were necessary to fully describe a Mycobacterium tuberculosis Beijing strain (ARA, Auvergne-Rhône-Alpes region) outbreak in France. The index case was a migrant from Cape Verde with a two-year history of tuberculosis, high bacillary load, and frequent trips within France and to Portugal. We designed an ARA-specific PCR to complete the tracking of this outbreak strain. The ARA-specific PCR was applied on 160 Beijing isolates from independent cases from the Auvergne-Rhône-Alpes region and on 25 cases from Cape Verde migrants in the Île-de-France region. No more cases were found, indicating that the previous surveillance had been exhaustive enough to capture the whole dimension of the outbreak in France. Next, we performed a cross-border surveillance, applying the PCR on 38 Beijing isolates in Portuthe gal. In all four cases (all migrants from Cape Verde) the ARA strain was identified. Whole genome sequences analysis of all ARA isolates representatives indicated a diversification of the strain into two variants present one in France and one in Portugal This work was supported by ERANet-LAC [ELAC2015/T08-0664] and Instituto de Salud Carlos III [AC16/00057, FIS15/01554, FIS13/ 01207, CP15/00075, PI16/01449, 1PI19/00331] and cofounded by European Regional Development Funds from the European Commission: “A way of making Europe”. Miguel Servet Contract CP15/00075 and CPII20/00001) to LPL. JP [CEECIND/00394/2017] is supported by FCT through Estímulo Individual ao Emprego Cientifico. Peer reviewed Elsevier http://hdl.handle.net/10261/284037 |
| title |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France |
| spellingShingle |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France Genestet, Charlotte Tuberculosis Outbreak Beijing Cross-border WGS Strain-specific PCR |
| title_short |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France |
| title_full |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France |
| title_fullStr |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France |
| title_full_unstemmed |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France |
| title_sort |
Expanded tracking of a Beijing Mycobacterium tuberculosis strain involved in an outbreak in France |
| author |
Genestet, Charlotte |
| author_facet |
Genestet, Charlotte Perdigão, João Herranz, Marta Maus, Sandra R. Pérez Lago, Laura Berland, Jean-Luc Chiner-Oms, Álvaro Comas, Iñaki Muñoz, Patricia Portugal, Isabel Dumitrescu, Oana García de Viedma, Darío |
| author_role |
author |
| author2 |
Perdigão, João Herranz, Marta Maus, Sandra R. Pérez Lago, Laura Berland, Jean-Luc Chiner-Oms, Álvaro Comas, Iñaki Muñoz, Patricia Portugal, Isabel Dumitrescu, Oana García de Viedma, Darío |
| author2_role |
author author author author author author author author author author author |
| topic |
Tuberculosis Outbreak Beijing Cross-border WGS Strain-specific PCR |
| topic_facet |
Tuberculosis Outbreak Beijing Cross-border WGS Strain-specific PCR |
| description |
14 páginas, 3 figuras, 1 tabla |
| publishDate |
2021 |
| format |
article |
| status_str |
acceptedVersion |
| url |
http://hdl.handle.net/10261/284037 |
| eu_rights_str_mv |
openAccess |
| publisher |
Elsevier |
| institution |
Consejo Superior de Investigaciones Científicas (CSIC) |
| collection |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| reponame_str |
DIGITAL.CSIC. Repositorio Institucional del CSIC |
| instname_str |
Consejo Superior de Investigaciones Científicas (CSIC) |
| _version_ |
1878439694288551936 |
| publishDateSort |
2021 |
| author_browse |
Berland, Jean-Luc Chiner-Oms, Álvaro Comas, Iñaki Dumitrescu, Oana García de Viedma, Darío Genestet, Charlotte Herranz, Marta Maus, Sandra R. Muñoz, Patricia Perdigão, João Portugal, Isabel Pérez Lago, Laura |
| publisherStr |
Elsevier |
| score |
6,9303427 |