Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?

Uveal melanoma is considered a rare disease but it is the most common intraocular malignancy in adults. Local treatments are effective, but the systemic recurrence rate is unacceptably high. Moreover, once metastasis have developed the prognosis is poor, with a 5-year survival rate of less than 5%,...

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Autores: Castet, Florian, García Mulero, Sandra, Sanz Pamplona, Rebeca, Cuellar, Andres, Casanovas i Casanovas, Oriol, Caminal Mitjana, Josep Maria, Piulats, Josep M.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/174839
Acceso en línea:https://hdl.handle.net/2445/174839
Access Level:acceso abierto
Palabra clave:Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Ophthalmopathies
Neovascularization
Immunotherapy
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spelling Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope? Castet, Florian García Mulero, Sandra Sanz Pamplona, Rebeca Cuellar, Andres Casanovas i Casanovas, Oriol Caminal Mitjana, Josep Maria Piulats, Josep M. Melanoma Oftalmopaties Angiogènesi Immunoteràpia Ophthalmopathies Neovascularization Immunotherapy Uveal melanoma is considered a rare disease but it is the most common intraocular malignancy in adults. Local treatments are effective, but the systemic recurrence rate is unacceptably high. Moreover, once metastasis have developed the prognosis is poor, with a 5-year survival rate of less than 5%, and systemic therapies, including immunotherapy, have rendered poor results. The tumour biology is complex, but angiogenesis is a highly important pathway in these tumours. Vasculogenic mimicry, the ability of melanomas to generate vascular channels independently of endothelial cells, could play an important role, but no effective therapy targeting this process has been developed so far. Angiogenesis modulates the tumour microenvironment of melanomas, and a close interplay is established between them. Therefore, combining immune strategies with drugs targeting angiogenesis offers a new therapeutic paradigm. In preclinical studies, these approaches effectively target these tumours, and a phase I clinical study has shown encouraging results in cutaneous melanomas. In this review, we will discuss the importance of angiogenesis in uveal melanoma, with a special focus on vasculogenic mimicry, and describe the interplay between angiogenesis and the tumour microenvironment. In addition, we will suggest future therapeutic approaches based on these observations and mention ways in which to potentially enhance current treatments. MDPI https://hdl.handle.net/2445/174839
title Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
spellingShingle Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
Castet, Florian
Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Ophthalmopathies
Neovascularization
Immunotherapy
title_short Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_full Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_fullStr Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_full_unstemmed Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
title_sort Uveal Melanoma, Angiogenesis and Immunotherapy, Is There Any Hope?
author Castet, Florian
author_facet Castet, Florian
García Mulero, Sandra
Sanz Pamplona, Rebeca
Cuellar, Andres
Casanovas i Casanovas, Oriol
Caminal Mitjana, Josep Maria
Piulats, Josep M.
author_role author
author2 García Mulero, Sandra
Sanz Pamplona, Rebeca
Cuellar, Andres
Casanovas i Casanovas, Oriol
Caminal Mitjana, Josep Maria
Piulats, Josep M.
author2_role author
author
author
author
author
author
topic Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Ophthalmopathies
Neovascularization
Immunotherapy
topic_facet Melanoma
Oftalmopaties
Angiogènesi
Immunoteràpia
Ophthalmopathies
Neovascularization
Immunotherapy
description Uveal melanoma is considered a rare disease but it is the most common intraocular malignancy in adults. Local treatments are effective, but the systemic recurrence rate is unacceptably high. Moreover, once metastasis have developed the prognosis is poor, with a 5-year survival rate of less than 5%, and systemic therapies, including immunotherapy, have rendered poor results. The tumour biology is complex, but angiogenesis is a highly important pathway in these tumours. Vasculogenic mimicry, the ability of melanomas to generate vascular channels independently of endothelial cells, could play an important role, but no effective therapy targeting this process has been developed so far. Angiogenesis modulates the tumour microenvironment of melanomas, and a close interplay is established between them. Therefore, combining immune strategies with drugs targeting angiogenesis offers a new therapeutic paradigm. In preclinical studies, these approaches effectively target these tumours, and a phase I clinical study has shown encouraging results in cutaneous melanomas. In this review, we will discuss the importance of angiogenesis in uveal melanoma, with a special focus on vasculogenic mimicry, and describe the interplay between angiogenesis and the tumour microenvironment. In addition, we will suggest future therapeutic approaches based on these observations and mention ways in which to potentially enhance current treatments.
publishDate 2019
format article
status_str publishedVersion
url https://hdl.handle.net/2445/174839
eu_rights_str_mv openAccess
publisher MDPI
institution Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
collection Recercat. Dipósit de la Recerca de Catalunya
reponame_str Recercat. Dipósit de la Recerca de Catalunya
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
_version_ 1878440141442252800
publishDateSort 2019
author_browse Caminal Mitjana, Josep Maria
Casanovas i Casanovas, Oriol
Castet, Florian
Cuellar, Andres
García Mulero, Sandra
Piulats, Josep M.
Sanz Pamplona, Rebeca
publisherStr MDPI
score 6.924472

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