Nontypable Haemophilus influenzae displays a prevalent surface structure molecular pattern in clinical isolates.

Non-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic variability among NTHi strains. In this study...

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Bibliographic Details
Authors: Martí Lliteras, Pau, López Gómez, A., Mauro, S., Hood, D.W., Viadas, Cristina, Calatayud, Laura, Morey, P., Servin, A., Liñares Louzao, Josefina, Oliver, Antonio, Bengoechea, José Antonio, Garmendia, Junkal
Format: article
Status:Published version
Publication Date:2011
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/44085
Online Access:https://hdl.handle.net/2445/44085
Access Level:Open access
Keyword:Bacteris patògens
Malalties de l'aparell respiratori
Genètica molecular
Pathogenic bacteria
Respiratory organs diseases
Molecular genetics
Description
Summary:Non-typable Haemophilus influenzae (NTHi) is a Gram negative pathogen that causes acute respiratory infections and is associated with the progression of chronic respiratory diseases. Previous studies have established the existence of a remarkable genetic variability among NTHi strains. In this study we show that, in spite of a high level of genetic heterogeneity, NTHi clinical isolates display a prevalent molecular feature, which could confer fitness during infectious processes. A total of 111 non-isogenic NTHi strains from an identical number of patients, isolated in two distinct geographical locations in the same period of time, were used to analyse nine genes encoding bacterial surface molecules, and revealed the existence of one highly prevalent molecular pattern (lgtF+, lic2A+, lic1D+, lic3A+, lic3B+, siaA−, lic2C+, ompP5+, oapA+) displayed by 94.6% of isolates. Such a genetic profile was associated with a higher bacterial resistance to serum mediated killing and enhanced adherence to human respiratory epithelial cells.

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